Publication: Enhanced maturation and proliferation of β-thalassemia/Hb E erythroid precursor cells in culture
Issued Date
2005-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-30344444000
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.5 (2005), 1298-1303
Suggested Citation
Yaowaree Kittikalayawong, Monnipha Sila-asna, Ahnond Bunyaratvej Enhanced maturation and proliferation of β-thalassemia/Hb E erythroid precursor cells in culture. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.5 (2005), 1298-1303. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16847
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Title
Enhanced maturation and proliferation of β-thalassemia/Hb E erythroid precursor cells in culture
Abstract
Upon erythroid cell maturation in vivo, β-thalassemic erythroid cells accumulate unmatched unstable α-globin chains that are believed to be a causal factor in such cell destruction. This study showed that β-thalassemia/Hb E erythroid precursor cells from peripheral blood had accelerated maturation, and could mature to the terminal erythroid stage. During the early period of cell culture, erythroid precursor cells derived from subjects with the more severe form of β-thalassemia/Hb E had higher rate of erythroid maturation. In addition, peripheral blood mononuclear cells from β-thalassemia/Hb E subjects had higher erythroid proliferative potential than cells derived from normal controls. Erythroid proportion in the more severe β-thalassemia/Hb E cases was less than that of the milder cases. Premature apoptosis was not observed during the 15 days of erythroid cell culture from both β-thalassemia/Hb E and normal subjects.