Publication: Inhibitory effects of Thai plants β-glycosides on Trichomonas vaginalis
Issued Date
2008-07-01
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ISSN
09320113
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2-s2.0-44349194840
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology Research. Vol.103, No.2 (2008), 443-448
Suggested Citation
Dumrongkiet Arthan, Somphong Sithiprom, Kanthinich Thima, Chutima Limmatvatirat, Porntip Chavalitshewinkoon-Petmitr, Jisnuson Svasti Inhibitory effects of Thai plants β-glycosides on Trichomonas vaginalis. Parasitology Research. Vol.103, No.2 (2008), 443-448. doi:10.1007/s00436-008-0996-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19318
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Title
Inhibitory effects of Thai plants β-glycosides on Trichomonas vaginalis
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Abstract
Trichomoniasis is now an important health problem in developing countries. Although metronidazole has so far been widely used to treat this disease, the prevalence of metronidazole-resistant protozoa and unpleasant adverse effects have been found. In this study, natural products purified from Thai plants were, therefore, investigated for their effectiveness against Trichomonas vaginalis. The minimal inhibitory concentrations for all β-glycosides against Trichomonas vaginalis at 24 h were in a range of 6.25-12.5 μM. In addition, torvoside A and H were found to be more potent than their corresponding aglycones, deglucosylated torvoside A and H, while other β-glycosides were generally as active as their corresponding aglycones. The cytotoxicity of these compounds was also determined. Except for dalcochinin, none of the tested compounds showed cytotoxicity against Vero and cancer cell lines (KB and MCF-7), having IC50values greater than 50 μg/ml. In conclusion, β-glycosides and several aglycones showed selective inhibition against Trichomonas vaginalis without harmful effect to mammalian cells. © 2008 Springer-Verlag.