Publication: Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
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Issued Date
2000-12-01
Resource Type
ISSN
01251562
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2-s2.0-0034574687
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.4 (2000), 663-667
Suggested Citation
Parnpen Viriyavejakul, Porntip Rojanasunan, Akravudh Viriyavejakul, Phaiboon Punyarit, Benjanee Punpoowong, Vasant Khachansaksumet, Mario Riganti, Emsri Pongponratn Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.4 (2000), 663-667. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26103
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Title
Opportunistic infections in the liver of HIV-infected patients in Thailand: A necropsy study
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Abstract
Liver necropsy from patients infected with human immunodeficiency virus was analyzed in 117 cases. Wide ranges of opportunistic infections were recorded in 47%. Cryptococcosis (21.4%) was the most outstanding infection, followed by tuberculosis (16.2%), cytomegalovirus (5.1%) and penicillosis (3.4%). Non-specific alterations of the liver tissues included fatty steatosis (49.6%), fibrosis (55.6%), portal inflammation and reactive hepatitis. Cases of chronic active and chronic passive hepatitis and one case of hepatocellular carcinoma were reported. In the infected liver, predominant pathological changes included granuloma and spotty necrosis, which were attributed to tuberculous hepatitis. Infection with Cryptococcus usually showed no associated pathological change. The sensitivity for the clinical diagnosis of Cryptococcus was 88.8% and specificity was 91.7%. For tuberculosis, sensitivity was 20% and specificity was 67.9%.