Publication: Combretastatins D-3 and D-4, new macrocyclic lactones from Getonia floribunda
Issued Date
2005-02-01
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-14944387128
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Planta Medica. Vol.71, No.2 (2005), 191-193
Suggested Citation
Namphung Vongvanich, Prasat Kittakoop, Panarat Charoenchai, Sutichai Intamas, Kannawat Danwisetkanjana, Yodhathai Thebtaranonth Combretastatins D-3 and D-4, new macrocyclic lactones from Getonia floribunda. Planta Medica. Vol.71, No.2 (2005), 191-193. doi:10.1055/s-2005-837791 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16380
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Combretastatins D-3 and D-4, new macrocyclic lactones from Getonia floribunda
Other Contributor(s)
Abstract
Chemical investigation of biologically active compounds of Getonia floribunda led to the isolation of two new macrocyclic lactones, combretastatins D-3 (1) and D-4 (2). The structures of these compounds were confirmed by spectroscopic analyses. Combretastatin D-3 (1) exhibited cytotoxicity towards the small-cell lung cancer cell line (NCI-H187, IC50 = 13.0 ± 0.2 μg/mL) but was inactive against KB, BC-1, and Vero cell lines. Combretastatin D-3 (1) showed weak antitubercular activity with a minimum inhibitory concentration (MIC) of 100.0 μg/mL, and was inactive towards the malarial parasite. Combretastatin D-4 (2) was inactive in all antitubercular, antiplasmodial, and cytotoxic assays.