Publication: Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity
Issued Date
2013-01-01
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ISSN
15321991
01434160
01434160
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2-s2.0-84875255430
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Mahidol University
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SCOPUS
Bibliographic Citation
Cell Calcium. Vol.53, No.4 (2013), 256-263
Suggested Citation
Wilasinee Suwanjang, Kira M. Holmström, Banthit Chetsawang, Andrey Y. Abramov Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium. Vol.53, No.4 (2013), 256-263. doi:10.1016/j.ceca.2012.12.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31381
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Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity
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Abstract
Glucocorticoids are steroid hormones which act through the glucocorticoid receptor. They regulate a wide variety of biological processes. Two glucocorticoids, the naturally occurring corticosterone and chemically produced dexamethasone, have been used to investigate the effect of glucocorticoids on Ca2+-signalling in cortical co-cultures of neurons and astrocytes. Dexamethasone and to a lesser degree corticosterone both induced a decrease in cytosolic Ca2+concentration in neurons and astrocytes. The effect of both compounds can be blocked by inhibition of the plasmamembrane ATPase, calmodulin and by application of a glucocorticoid receptor antagonist, while inhibition of NMDA receptors or the endoplasmic reticulum calcium pump had no effect. Glucocorticoid treatment further protects against detrimental calcium signalling and cell death by modulating the delayed calcium deregulation in response to glutamate toxicity. At the concentrations used dexamethasone and corticosterone did not show cell toxicity of their own. Thus, these results indicate that dexamethasone and corticosterone might be used for protection of the cells from calcium overload. © 2013 Elsevier Ltd.