Publication: HMGB1: A new marker for estimation of the postmortem interval
1
Issued Date
2010-01-01
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ISSN
17921015
17920981
17920981
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2-s2.0-77955784283
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental and Therapeutic Medicine. Vol.1, No.1 (2010), 109-111
Suggested Citation
Kiyoshi Kikuchi, Ko ichi Kawahara, Kamal Krishna Biswas, Takashi Ito, Salunya Tancharoen, Naoto Shiomi, Yoshiro Koda, Fumiyo Matsuda, Yoko Morimoto, Yoko Oyama, Kazunori Takenouchi, Naoki Miura, Noboru Arimura, Yuko Nawa, Shinichiro Arimura, Meng Xiao Jie, Binita Shrestha, Masahiro Iwata, Kentaro Mera, Hisayo Sameshima, Yoshiko Ohno, Ryuichi Maenosono, Yutaka Tajima, Hisaaki Uchikado, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Yoshihiro Yoshida, Teruto Hashiguchi, Ikuro Maruyama HMGB1: A new marker for estimation of the postmortem interval. Experimental and Therapeutic Medicine. Vol.1, No.1 (2010), 109-111. doi:10.3892/etm_00000019 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28848
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Title
HMGB1: A new marker for estimation of the postmortem interval
Author(s)
Kiyoshi Kikuchi
Ko ichi Kawahara
Kamal Krishna Biswas
Takashi Ito
Salunya Tancharoen
Naoto Shiomi
Yoshiro Koda
Fumiyo Matsuda
Yoko Morimoto
Yoko Oyama
Kazunori Takenouchi
Naoki Miura
Noboru Arimura
Yuko Nawa
Shinichiro Arimura
Meng Xiao Jie
Binita Shrestha
Masahiro Iwata
Kentaro Mera
Hisayo Sameshima
Yoshiko Ohno
Ryuichi Maenosono
Yutaka Tajima
Hisaaki Uchikado
Terukazu Kuramoto
Kenji Nakayama
Minoru Shigemori
Yoshihiro Yoshida
Teruto Hashiguchi
Ikuro Maruyama
Ko ichi Kawahara
Kamal Krishna Biswas
Takashi Ito
Salunya Tancharoen
Naoto Shiomi
Yoshiro Koda
Fumiyo Matsuda
Yoko Morimoto
Yoko Oyama
Kazunori Takenouchi
Naoki Miura
Noboru Arimura
Yuko Nawa
Shinichiro Arimura
Meng Xiao Jie
Binita Shrestha
Masahiro Iwata
Kentaro Mera
Hisayo Sameshima
Yoshiko Ohno
Ryuichi Maenosono
Yutaka Tajima
Hisaaki Uchikado
Terukazu Kuramoto
Kenji Nakayama
Minoru Shigemori
Yoshihiro Yoshida
Teruto Hashiguchi
Ikuro Maruyama
Abstract
Estimation of the postmortem interval (PMIPMIPMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMHMGB1), a nonhistone DNADNADNA-binding protein is released by eukaryotic cells upon necrosis. Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4, 14 and 24 °C since death were measured by enzyme-linked immunosorbent assay. The serum HMHMGB1 level showed a time-dependent increase up to seven days at 4 °C. At 14 °C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued. At 24 °C, the HMHMGB1 level peaked at day 2, decreased at day 3, and then plateaued. Our findings suggest that HMGB1 is related to the PMIPMIPMI in rats.