Publication: Immunoglobulin GM and KM genotypes in hepatitis C virus infection
Issued Date
2004-07-01
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ISSN
01466615
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2-s2.0-2542445410
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Medical Virology. Vol.73, No.3 (2004), 384-386
Suggested Citation
Sasijit Vejbaesya, Taweesak Tanwandee, Janardan P. Pandey Immunoglobulin GM and KM genotypes in hepatitis C virus infection. Journal of Medical Virology. Vol.73, No.3 (2004), 384-386. doi:10.1002/jmv.20102 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21373
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Title
Immunoglobulin GM and KM genotypes in hepatitis C virus infection
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Abstract
Hepatitis C virus (HCV) is a major health problem, affecting over 170 million people worldwide. HCV causes a wide spectrum of liver disease, varying from persistent to asymptomatic infection. To evaluate the role of immunoglobulin (lg) GM and KM genes in HCV infection, 191 HCV-infected Thai subjects were studied. These included 43 individuals with transient HCV infection and 148 individuals with persistent chronic HCV infection. The controls consisted of 134 healthy individuals. Several GM and KM alleles were determined by polymerase chain reaction-based methods. The frequency of G1M(f) homozygotes was lower (52.4% vs. 64.2%, P= 0.03) and the frequency of G 1M(z) homozygotes was higher (10.5% vs. 3.7%, P= 0.02) in patients than the respective frequencies in controls. These results suggest that GM genotypes make a significant contribution to the risk of acquiring HCV infection. © 2004 Wiley-Liss, Inc.