Publication: Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer
Issued Date
2012-08-02
Resource Type
ISSN
1572896X
13880764
13880764
Other identifier(s)
2-s2.0-84864347157
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Nanoparticle Research. Vol.14, No.8 (2012)
Suggested Citation
C. Thammawong, P. Sreearunothai, A. Petchsuk, P. Tangboriboonrat, N. Pimpha, P. Opaprakasit Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer. Journal of Nanoparticle Research. Vol.14, No.8 (2012). doi:10.1007/s11051-012-1046-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13908
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Title
Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer
Abstract
Naproxen (NPX) drug-loaded magnetic nanoparticles (MNPs) have been prepared in a one-step process utilizing a biocompatible polylactide-grafted-chitosan copolymer. The copolymer serves both as a NPX drug carrier as well as a polymeric surfactant for the synthesis of MNPs without the use of any additional surfactant. Highly stable MNPs with high magnetization in the form of maghemite (γ-Fe 2 O 3 ) are prepared in aqueous media. Effects of preparation conditions on structures and properties of the copolymer-coated and drug-loaded MNPs are investigated by employing particle size and zeta potential measurements, transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction, Fourier-transform infrared, nuclear magnetic resonance, and confocal Raman spectroscopy. The results show that average particle size (150-300 nm), coating efficiency, and coating structures of the resulting MNPs materials are strongly dependent on MNP/copolymer and MNP/NPX ratios in feed. It is also observed that NPX acts as co-surfactant in the drug-loading pro cess, resulting in different encapsulating structures with the variation in the MNP/copolymer and MNP/NPX ratios. Properties of the MNPs materials can be further optimized for use in specific biomedical applications. © 2012 Springer Science+Business Media B.V.