Publication:
Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases

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dc.contributor.authorNiklas Lindegardhen_US
dc.contributor.authorGeraint R. Daviesen_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorJeremy Farraren_US
dc.contributor.authorPratap Sinehasivanonen_US
dc.contributor.authorNicholas P J Dayen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherUniversity of Liverpoolen_US
dc.contributor.otherUCLen_US
dc.date.accessioned2018-08-20T07:12:52Z
dc.date.available2018-08-20T07:12:52Z
dc.date.issued2006-09-01en_US
dc.description.abstractThe anti-influenza drug oseltamivir is an ester prod rug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3197-3199en_US
dc.identifier.doi10.1128/AAC.00500-06en_US
dc.identifier.issn00664804en_US
dc.identifier.other2-s2.0-33748685657en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/23636
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748685657&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleRapid degradation of oseltamivir phosphate in clinical samples by plasma esterasesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748685657&origin=inwarden_US

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