Publication: The efficacy of 5% imiquimod cream in the prevention of recurrence of excised keloids
Issued Date
2007-07-01
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ISSN
01252208
01252208
01252208
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2-s2.0-34548531478
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.90, No.7 (2007), 1363-1367
Suggested Citation
Apirag Chuangsuwanich, Suriya Gunjittisomrarn The efficacy of 5% imiquimod cream in the prevention of recurrence of excised keloids. Journal of the Medical Association of Thailand. Vol.90, No.7 (2007), 1363-1367. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24824
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Title
The efficacy of 5% imiquimod cream in the prevention of recurrence of excised keloids
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Abstract
Objective: To evaluate the efficacy of 5% imiquimod cream in the prevention of recurrence of excised keloids. Material and Method: The patients with keloids that had occurred over 1 year and could be excised and primary sutured were enrolled in the study. Imiquimod 5% cream was applied to the scar 7 days after stitches removal. The patients were follow-up for recurrence and drug side effect at 4, 6, 8, 16, and 24 weeks Results: Forty-five patients enrolled to the study but only 35 patients finished the study. The keloids were at the pinnas in 22 patients, at the backs or shoulders in 7 patients, and at chest walls or necks in 6 patients. Imiquimod 5% cream was applied on the wound area 2 weeks after the operation, at alternate night for 8 weeks. The follow-up period ranged from 6 to 9 months. Ten of the treated keloids recurred (28.6% recurrent rate). The lesion at the pinna had the lowest recurrent rate (2.9% recurrent of the total patients). The highest recurrent rate occurred at the chest wall or neck (83.3% recurrent of the chest wall or neck or 14.3% of the total patients). Side effects were found in thirteen patients (37.1%). These were abrasions of the skin around the wound areas in ten patients and hyperpigmentation of the skin around the wounds in three patients. Conclusion: Imiquimod 5% cream could effectively prevent recurrence of the excised keloids, especially in the area that had less tension such as pinna.