Publication: The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers
Issued Date
2011-01-01
Resource Type
ISSN
13826689
Other identifier(s)
2-s2.0-78650216205
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Environmental Toxicology and Pharmacology. Vol.31, No.1 (2011), 160-164
Suggested Citation
Krittaya Petchpoung, Sming Kaojarern, Krongtong Yoovathaworn, Thanyachai Sura, Jintana Sirivarasai The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers. Environmental Toxicology and Pharmacology. Vol.31, No.1 (2011), 160-164. doi:10.1016/j.etap.2010.10.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11932
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers
Other Contributor(s)
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are associated with an increased cancer risk. CYP1A1 and GSTs enzymes are important in metabolism of PAHs. Genetic polymorphisms of these enzymes are responsible for enzyme activity and concentration variation. The objectives of this study were to evaluate association of 1-OHP concentration with genetic polymorphisms of CYP1A1and GSTs in Thai bus drivers. The results showed that 1-OHP levels in bus drivers were significantly higher than that in the control group. Significant difference in 1-OHP was found between smokers and non-smokers, in only bus drivers. Significantly increasing of 1-OHP levels were observed in bus drivers with CYP1A1 MspI and exon 7 variants. Whereas, bus drivers with GSTP1 Val and GSTM1 null genotypes showed decreasing in excretion of 1-OHP. No association between 1-OHP and polymorphisms of GSTT1 was found. This study indicated that 1-OHP concentrations were associated with exposure to air pollution, cigarette smoking and polymorphisms of CYP1A1, GSTM1 and GSTP1 genes. © 2010 Elsevier B.V.