Publication: The future outlook of antimalarial drugs and recent work on the treatment of malaria
Issued Date
2002-07-01
Resource Type
ISSN
01884409
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2-s2.0-0036662075
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Medical Research. Vol.33, No.4 (2002), 416-421
Suggested Citation
Polrat Wilairatana, Srivicha Krudsood, Sombat Treeprasertsuk, Kobsiri Chalermrut, Sornchai Looareesuwan The future outlook of antimalarial drugs and recent work on the treatment of malaria. Archives of Medical Research. Vol.33, No.4 (2002), 416-421. doi:10.1016/S0188-4409(02)00371-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20468
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Title
The future outlook of antimalarial drugs and recent work on the treatment of malaria
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Abstract
Background. With the emergence of multidrug-resistant falciparum malaria, new drugs and drugs in combination are urgently needed. Methods. New antimalarial drugs investigated at the Hospital for Tropical Diseases of the Faculty of Tropical Medicine at Mahidol University in Bangkok, Thailand in recent years for treatment of uncomplicated and severe falciparum malaria are as follows: atovaquone, and artemisinin derivatives (artesunate, artemether, arteether, and dihydroartemisinin) combined with other antimalarials. Results. Malarone®, artemisinin derivatives combined with lumefantrine or doxycycline, and mefloquine combined with tetracycline or doxycycline have been evaluated with improvement of the cure rate in uncomplicated malaria. Artemisinin derivatives intravenously or intrarectally combined with mefloquine may be alternatives to intravenous quinine for treatment of severe malaria. Conclusions. In Thailand, drug treatment for uncomplicated malaria consists of the combinations or artesunate plus mefloquine or artemether plus lumefantrine or quinine plus tetracycline. In treatment of severe malaria, antimalarial drugs of choice are intravenous quinine or artemisinin derivatives. © 2002 IMSS. Published by Elsevier Science Inc.