Publication: Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with Metabolic Syndrome and Periodontitis.
Accepted Date
2016-01-21
Issued Date
2016-02-12
Resource Type
Language
eng
ISSN
(electronic)
Rights
Mahidol University
Rights Holder(s)
Public Library of Science
Bibliographic Citation
Thanakun S, Pornprasertsuk-Damrongsri S, Gokyu M, Kobayashi H, Izumi Y. Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with metabolic syndrome and periodontitis. PLoS One 2016 Feb 12;112):e0148638.
Suggested Citation
Supanee Thanakun, สุพานี ธนาคุณ, Suchaya Pornprasertsuk-Damrongsri, สุชยา ดำรงค์ศรี, Gokyu, Misa, Kobayashi, Hiroaki, Izumi, Yuichi Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with Metabolic Syndrome and Periodontitis.. Thanakun S, Pornprasertsuk-Damrongsri S, Gokyu M, Kobayashi H, Izumi Y. Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with metabolic syndrome and periodontitis. PLoS One 2016 Feb 12;112):e0148638.. doi:10.1371/journal.pone.0148638. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/1001
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Title
Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with Metabolic Syndrome and Periodontitis.
Abstract
The association between clinically diagnosed periodontitis, a common chronic oral infection, and metabolic syndrome has been previously reported. The aim of this study was to investigate the association of plasma IgG levels against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia, C-reactive protein, and periodontal status with metabolic syndrome. Plasma IgG levels and C-reactive protein were measured by enzyme-linked immunosorbent assay, and salivary levels of A. actinomycetemcomitans and P. gingivalis were determined by quantitative real-time polymerase chain reaction. Among 127 individuals aged 35–76 years, 57 participants had metabolic syndrome and severe periodontitis, 25 had metabolic syndrome and an absence of severe periodontitis, 17 healthy individuals had severe periodontitis, and 28 healthy individuals were without severe periodontitis. Patients with metabolic syndrome had reduced humoral immune response to A. actinomycetemcomitans (p = 0.008), regardless of their salivary levels or periodontitis status compared with healthy participants. The IgG antibody response to P. gingivalis, regardless of their salivary levels or participants’ health condition, was significantly higher in severe periodontitis patients (p<0.001). Plasma IgG titers for P. intermedia were inconsistent among metabolic syndrome or periodontal participants. Our results indicate that the presence of lower levels of IgG antibodies to A. actinomycetemcomitans (OR = 0.1; 95%CI 0.0–0.7), but not P. gingivalis, a severe periodontitis status (OR = 7.8; 95%CI 1.1–57.0), high C-reactive protein levels (OR = 9.4; 95%CI 1.0–88.2) and body mass index (OR = 3.0; 95%CI 1.7–5.2), are associated with the presence of metabolic syndrome. The role of the decreased IgG antibody response to A. actinomycetemcomitans, increased C-reactive protein levels on the association between periodontal disease and metabolic syndrome in a group of Thai patients is suggested.