Publication: Predicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarker
Issued Date
2021-11-19
Resource Type
ISSN
25890042
Other identifier(s)
2-s2.0-85118764339
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
iScience. Vol.24, No.11 (2021)
Suggested Citation
Krittima Anekthanakul, Siriphan Manocheewa, Kittiphan Chienwichai, Patcha Poungsombat, Suphitcha Limjiasahapong, Kwanjeera Wanichthanarak, Narumol Jariyasopit, Vivek Bhakta Mathema, Chutima Kuhakarn, Vichai Reutrakul, Jutarop Phetcharaburanin, Atikorn Panya, Natthaporn Phonsatta, Wonnop Visessanguan, Yotsawat Pomyen, Yongyut Sirivatanauksorn, Suchin Worawichawong, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Sakda Khoomrung Predicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarker. iScience. Vol.24, No.11 (2021). doi:10.1016/j.isci.2021.103355 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79283
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Title
Predicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarker
Author(s)
Krittima Anekthanakul
Siriphan Manocheewa
Kittiphan Chienwichai
Patcha Poungsombat
Suphitcha Limjiasahapong
Kwanjeera Wanichthanarak
Narumol Jariyasopit
Vivek Bhakta Mathema
Chutima Kuhakarn
Vichai Reutrakul
Jutarop Phetcharaburanin
Atikorn Panya
Natthaporn Phonsatta
Wonnop Visessanguan
Yotsawat Pomyen
Yongyut Sirivatanauksorn
Suchin Worawichawong
Nuankanya Sathirapongsasuti
Chagriya Kitiyakara
Sakda Khoomrung
Siriphan Manocheewa
Kittiphan Chienwichai
Patcha Poungsombat
Suphitcha Limjiasahapong
Kwanjeera Wanichthanarak
Narumol Jariyasopit
Vivek Bhakta Mathema
Chutima Kuhakarn
Vichai Reutrakul
Jutarop Phetcharaburanin
Atikorn Panya
Natthaporn Phonsatta
Wonnop Visessanguan
Yotsawat Pomyen
Yongyut Sirivatanauksorn
Suchin Worawichawong
Nuankanya Sathirapongsasuti
Chagriya Kitiyakara
Sakda Khoomrung
Other Contributor(s)
Chulabhorn Research Institute
Siriraj Hospital
Hatyai Hospital
Faculty of Medicine, Khon Kaen University
Khon Kaen University
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Research Network of NANOTEC - MU Ramathibodi on Nanomedicine
Siriraj Hospital
Hatyai Hospital
Faculty of Medicine, Khon Kaen University
Khon Kaen University
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Research Network of NANOTEC - MU Ramathibodi on Nanomedicine
Abstract
The current gold standard for classifying lupus nephritis (LN) progression is a renal biopsy, which is an invasive procedure. Undergoing a series of biopsies for monitoring disease progression and treatments is unlikely suitable for patients with LN. Thus, there is an urgent need for non-invasive alternative biomarkers that can facilitate LN class diagnosis. Such biomarkers will be very useful in guiding intervention strategies to mitigate or treat patients with LN. Urine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathology. Metabolomics was performed to identify potential metabolites, which could be specific for the classification of membranous LN. The ratio of picolinic acid (Pic) to tryptophan (Trp) ([Pic/Trp] ratio) was found to be a promising candidate for LN diagnostic and membranous classification. It has high potential as an alternative biomarker for the non-invasive diagnosis of LN.