Publication: Situs inversus totalis and ultrastructure of respiratory cilia: Report of a cadaveric case
Issued Date
2012-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-84856871058
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.95, No.1 (2012), 132-138
Suggested Citation
Jantima Roongruangchai, Wanida Narongsak, Vasana Plakornkul, Yadaridee Viravud, Kesorn Sripaoraya, Kosol Roongruangchai Situs inversus totalis and ultrastructure of respiratory cilia: Report of a cadaveric case. Journal of the Medical Association of Thailand. Vol.95, No.1 (2012), 132-138. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15066
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Situs inversus totalis and ultrastructure of respiratory cilia: Report of a cadaveric case
Other Contributor(s)
Abstract
Situs inversus totalis is the complete reversal of positions of major thoracic and abdominal organs. The present study reports the reversed structures and histology of the epithelium of bronchus of a female cadaver, 87 years of age, which was found during the dissection in a medical course of gross anatomy. Opening the thoracic cage, the apex of heart was projected to the right side (dextrocardia) while the right and left lungs were alternated. Intra-abdominal organs were also completely alternated, as the liver situated on the left while spleen on the right and the same as the abdominal intestinal tract. The superior and inferior vena cavae located on the left side and drained blood into the left atrium. The azygos vein was on the right. The histology of the epithelium of bronchus and the transmission electron microscopy of the cilium ultrastructure were normal. Cardiac displacement seems to be associated with malrotation of the heart tube leads to dextrocardia and causes the inversion of positions of the thoracic and abdominal organs. The incidence of situs inversus totalis is approximately 1: 10,000 and may be associated with primary ciliary dyskinesia (PCD) which refers to the dysfunction of cilia. PCD is also known as Kartagener syndrome (KS) which is characterized by situs inversus, bronchiectasis, chronic sinusitis and infertility, KS represents 20-25% of situs inversus totalis. However, in the present study, the histology and ultrastructure of cilia appear normal.