Publication: HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA
Issued Date
1987-03-28
Resource Type
ISSN
01406736
Other identifier(s)
2-s2.0-0023103104
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Lancet. Vol.329, No.8535 (1987), 708-711
Suggested Citation
N. J. White, K. Marsh, R. C. Turner, K. D. Miller, C. D. Berry, D. H. Williamson, J. Brown HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA. The Lancet. Vol.329, No.8535 (1987), 708-711. doi:10.1016/S0140-6736(87)90354-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15422
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Title
HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA
Abstract
Hypoglycaemia, defined as a plasma glucose concentration below 2·2 mmol/l, developed in 15 of 47 prospectively studied Gambian children with severe chloroquine-sensitive falciparum malaria. 5 of these hypoglycaemic children died compared with 1 in the normoglycaemic group (p = 0·02). In contrast to previous observations in quinine-treated adults, in whom hypoglycaemia was associated with hyperinsulinaemia, plasma concentrations of insulin were appropriately low and plasma ketones were high. Raised plasma concentrations of lactate and alanine suggested impairment of hepatic gluconeogenesis. In African children, hypoglycaemia is an important and treatable manifestation of severe malaria and is unrelated to antimalarial treatment. © 1987.