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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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dc.contributor.authorMomoko Horikoshien_US
dc.contributor.authorHanieh Yaghootkaren_US
dc.contributor.authorDennis O. Mook-Kanamorien_US
dc.contributor.authorUlla Sovioen_US
dc.contributor.authorH. Rob Taalen_US
dc.contributor.authorBranwen J. Hennigen_US
dc.contributor.authorJonathan P. Bradfielden_US
dc.contributor.authorBeate St Pourcainen_US
dc.contributor.authorDavid M. Evansen_US
dc.contributor.authorPimphen Charoenen_US
dc.contributor.authorMarika Kaakinenen_US
dc.contributor.authorDiana L. Cousmineren_US
dc.contributor.authorTerho Lehtimäkien_US
dc.contributor.authorEskil Kreiner-Mølleren_US
dc.contributor.authorNicole M. Warringtonen_US
dc.contributor.authorMariona Bustamanteen_US
dc.contributor.authorBjarke Feenstraen_US
dc.contributor.authorDiane J. Berryen_US
dc.contributor.authorElisabeth Thieringen_US
dc.contributor.authorThiemo Pfaben_US
dc.contributor.authorSheila J. Bartonen_US
dc.contributor.authorBeverley M. Shieldsen_US
dc.contributor.authorMarjan Kerkhofen_US
dc.contributor.authorElisabeth M. Van Leeuwenen_US
dc.contributor.authorAnthony J. Fulforden_US
dc.contributor.authorZoltán Kutaliken_US
dc.contributor.authorJing Hua Zhaoen_US
dc.contributor.authorMarcel Den Hoeden_US
dc.contributor.authorAnubha Mahajanen_US
dc.contributor.authorVirpi Lindien_US
dc.contributor.authorLiang Kee Gohen_US
dc.contributor.authorJouke Jan Hottengaen_US
dc.contributor.authorYing Wuen_US
dc.contributor.authorOlli T. Raitakarien_US
dc.contributor.authorMarie N. Harderen_US
dc.contributor.authorAline Meirhaegheen_US
dc.contributor.authorIoanna Ntallaen_US
dc.contributor.authorRany M. Salemen_US
dc.contributor.authorKaren A. Jamesonen_US
dc.contributor.authorKaixin Zhouen_US
dc.contributor.authorDorota M. Moniesen_US
dc.contributor.authorVasiliki Lagouen_US
dc.contributor.authorMirna Kirinen_US
dc.contributor.authorJani Heikkinenen_US
dc.contributor.authorLinda S. Adairen_US
dc.contributor.authorFowzan S. Alkurayaen_US
dc.contributor.authorAli Al-Odaiben_US
dc.contributor.authorPhilippe Amouyelen_US
dc.contributor.authorEhm Astrid Anderssonen_US
dc.contributor.authorAmanda J. Bennetten_US
dc.contributor.authorAlexandra I.F. Blakemoreen_US
dc.contributor.authorJessica L. Buxtonen_US
dc.contributor.authorJean Dallongevilleen_US
dc.contributor.authorShikta Dasen_US
dc.contributor.authorEco J.C. De Geusen_US
dc.contributor.authorXavier Estivillen_US
dc.contributor.authorClaudia Flexederen_US
dc.contributor.authorPhilippe Froguelen_US
dc.contributor.authorFrank Gelleren_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherUniversity of Exeteren_US
dc.contributor.otherErasmus University Medical Centeren_US
dc.contributor.otherWeill Cornell Medicine-Qataren_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherMedical Research Councilen_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.contributor.otherThe Children's Hospital of Philadelphiaen_US
dc.contributor.otherUniversity of Bristolen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherOulun Yliopistoen_US
dc.contributor.otherHelsingin Yliopistoen_US
dc.contributor.otherTampereen Yliopistoen_US
dc.contributor.otherUniversity Hospital of Tampereen_US
dc.contributor.otherUniversity of Copenhagen, Faculty of Health Sciencesen_US
dc.contributor.otherCopenhagen University Hospitalen_US
dc.contributor.otherUniversity of Western Australia Faculty of Medicine and Dentistryen_US
dc.contributor.otherCentre de Recerca en Epidemiologia Ambiental, Barcelonaen_US
dc.contributor.otherHospital del Maren_US
dc.contributor.otherCIBER Epidemiologia Y Salud Publicaen_US
dc.contributor.otherCentro de Regulacion Genomicaen_US
dc.contributor.otherStatens Serum Instituten_US
dc.contributor.otherUCL Institute of Child Healthen_US
dc.contributor.otherHelmholtz Center Munich German Research Center for Environmental Healthen_US
dc.contributor.otherCharité – Universitätsmedizin Berlinen_US
dc.contributor.otherUniversitat Potsdamen_US
dc.contributor.otherUniversity of Southamptonen_US
dc.contributor.otherUniversity of Groningen, University Medical Center Groningenen_US
dc.contributor.otherUniversitat Lausanne Schweizen_US
dc.contributor.otherSwiss Institute of Bioinformaticsen_US
dc.contributor.otherAddenbrooke's Hospitalen_US
dc.contributor.otherIta-Suomen yliopistoen_US
dc.contributor.otherDuke-NUS Graduate Medical School Singaporeen_US
dc.contributor.otherNational University of Singaporeen_US
dc.contributor.otherVrije Universiteit Amsterdamen_US
dc.contributor.otherThe University of North Carolina at Chapel Hillen_US
dc.contributor.otherTurun yliopistoen_US
dc.contributor.otherInsermen_US
dc.contributor.otherInstitut Pasteur Lilleen_US
dc.contributor.otherUniversity of Lilleen_US
dc.contributor.otherUniversite Lille 2 Droit et Santeen_US
dc.contributor.otherHarokopio Universityen_US
dc.contributor.otherChildren's Hospital Bostonen_US
dc.contributor.otherBroad Instituteen_US
dc.contributor.otherHarvard Medical Schoolen_US
dc.contributor.otherUniversity of Dundeeen_US
dc.contributor.otherKing Faisal Specialist Hospital and Research Centreen_US
dc.contributor.otherUniversity of Edinburghen_US
dc.contributor.otherKing Khaled Eye Specialist Hospitalen_US
dc.contributor.otherAlfaisal Universityen_US
dc.contributor.otherUniversitat Pompeu Fabraen_US
dc.contributor.otherHammersmith Hospitalen_US
dc.contributor.otherSouthampton University Hospitals NHS Trusten_US
dc.contributor.otherLille Inflammation Research International Centeren_US
dc.contributor.otherFaculty of Health Sciences, University of Southern Denmarken_US
dc.contributor.otherCentre for Medical Systems Biologyen_US
dc.contributor.otherAmtssygehuset i Glostrupen_US
dc.contributor.otherKobenhavns Universiteten_US
dc.contributor.otherUniversity of Athens Medical Schoolen_US
dc.contributor.otherUniversitat Leipzigen_US
dc.contributor.otherMedizinische Hochschule Hannover (MHH)en_US
dc.contributor.otherNorthwestern Universityen_US
dc.contributor.otherUniversity of Groningenen_US
dc.contributor.otherKlinikum der Universitat Munchenen_US
dc.contributor.otherRigshospitaleten_US
dc.contributor.otherSteno Diabetes Centeren_US
dc.date.accessioned2018-10-19T04:44:16Z
dc.date.available2018-10-19T04:44:16Z
dc.date.issued2013-01-01en_US
dc.description.abstractBirth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.en_US
dc.identifier.citationNature Genetics. Vol.45, No.1 (2013), 76-82en_US
dc.identifier.doi10.1038/ng.2477en_US
dc.identifier.issn15461718en_US
dc.identifier.issn10614036en_US
dc.identifier.other2-s2.0-84871987100en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31430
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871987100&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleNew loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolismen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871987100&origin=inwarden_US

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