Publication: Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro
Issued Date
2006-09-01
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13835769
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2-s2.0-33745894316
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology International. Vol.55, No.3 (2006), 195-199
Suggested Citation
Sunan Nakornchai, Phattanapong Konthiang Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro. Parasitology International. Vol.55, No.3 (2006), 195-199. doi:10.1016/j.parint.2005.11.058 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23305
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Title
Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro
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Abstract
Chlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the3H-hypoxanthine incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50values of 136.0 ± 40.2 μM and 102.0 ± 22.6 μM respectively. A combination of antimalarial drug and chlorpheniramine was tested against resistant P. falciparum in vitro. Isobologram analysis showed that chlorpheniramine exerts marked synergistic action on chloroquine against P. falciparum K1 and T9/94. Chlorpheniramine also potentiated antimalarial action of mefloquine, quinine or pyronaridine against both of the resistant strains of P. falciparum. However, chlorpheniramine antagonism with artesunate was obtained in both P. falciparum K1 and T9/94. The results in this study indicate that antihistaminic drugs may be promising candidates for potentiating antimalarial drug action against drug resistant malarial parasites. © 2006 Elsevier Ireland Ltd. All rights reserved.
