Publication: Comparison of salbutamol efficacy in children- via themetered-dose inhaler (MDI) with Volumatic<sup>®</sup>spacerand via the dry powder inhaler, Easyhaler<sup>®</sup>, with thenebulizer - in mild to moderate asthma exacerbation: A multicenter, randomized study
Issued Date
2011-03-01
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ISSN
22288694
0125877X
0125877X
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2-s2.0-79958266250
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.29, No.1 (2011), 25-33
Suggested Citation
Chalerat Direkwatanachai, Jamaree Teeratakulpisarn, Somchai Suntornlohanakul, Muthita Trakultivakorn, Jarungchit Ngamphaiboon, Nares Wongpitoon, Mukda Vangveeravong Comparison of salbutamol efficacy in children- via themetered-dose inhaler (MDI) with Volumatic<sup>®</sup>spacerand via the dry powder inhaler, Easyhaler<sup>®</sup>, with thenebulizer - in mild to moderate asthma exacerbation: A multicenter, randomized study. Asian Pacific Journal of Allergy and Immunology. Vol.29, No.1 (2011), 25-33. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12078
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Title
Comparison of salbutamol efficacy in children- via themetered-dose inhaler (MDI) with Volumatic<sup>®</sup>spacerand via the dry powder inhaler, Easyhaler<sup>®</sup>, with thenebulizer - in mild to moderate asthma exacerbation: A multicenter, randomized study
Abstract
Background: β 2 agonist administered via anebulizer is the standard treatment for acuteasthma exacerbation. There are somelimitations for the use of nebulization. Weconducted a study to determine the efficacy ofsalbutamol administered via the pMDI withVolumatic ® spacer and the Easyhaler ® (DPI)compared to nebulization in mild to moderateasthma exacerbations in children.Methods: A multicenter, randomized,controlled study was conducted in childrenbetween 5 and 18 years of age who presented atan emergency or outpatient department. Theywere randomized to receive either 6 puffs ofsalbutamol via the pMDI with Volumatic ® spacer, or via the Easyhaler ® , or 0.15 mg/kg ofsalbutamol nebulized via oxygen (orcompressed air). The primary outcome was theclinical response which was assessed using themodified Wood's asthma score. The secondaryoutcomes were: hospitalization, asthma revisitwithin 3 days, systemic corticosteroid useand adverse events. The clinical score, oxygensaturation, PR, RR, BP and adverse eventswere recorded at time 0 (before treatment) and 20, 40 and 60 minutes after drugadministration.Results: There were no statistically significantdifferences in the clinical response between thethree groups at the 1 st , 2 nd or 3 rd dose or for theSpO 2 or the respiratory rate while the childrenin the Easyhaler ® group had significantly lesstachycardia after the 2 nd dose. No significantadverse events were noted among the threegroups.Conclusions: Salbutamol administered via pMDIwith Volumatic ® spacer or DPI (Easyhaler ® ) areas effective as salbutamol given via a nebulizerin providing effective relief of mild to moderateseverity acute asthma exacerbation in childrenbetween 5 and 18 years of age.