Publication: Bioactivity-guided separation of the active compounds in acacia pennata responsible for the prevention of Alzheimer's disease
1
Issued Date
2015-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-84945999798
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.10, No.8 (2015), 1431-1434
Suggested Citation
Pattamapan Lomarat, Sirirat Chancharunee, Natthinee Anantachoke, Worawan Kitphati, Kittisak Sripha, Nuntavan Bunyapraphatsara Bioactivity-guided separation of the active compounds in acacia pennata responsible for the prevention of Alzheimer's disease. Natural Product Communications. Vol.10, No.8 (2015), 1431-1434. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35252
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Bioactivity-guided separation of the active compounds in acacia pennata responsible for the prevention of Alzheimer's disease
Other Contributor(s)
Abstract
The objective of this study was to evaluate the health benefits of plants used in Thai food, specifically Acacia pennata Willd., in Alzheimer's prevention. A. pennata twigs strongly inhibited β-amyloid aggregation. Bioactivity-guided separation of the active fractions yielded six known compounds, tetracosane (1), 1-(heptyloxy)-octadecane (2), methyl tridecanoate (3), arborinone (4), confertamide A (5) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6). The structures were determined by spectroscopic analysis. Biological testing revealed that tetracosane (1) was the most potent inhibitor of β-amyloid aggregation, followed by 1-(heptyloxy)-octadecane (2) with IC50values of 0.4 and 12.3 μM. Methyl tridecanoate (3), arborinone (4) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6) moderately inhibited β-amyloid aggregation. In addition, tetracosane (1) and methyl tridecanoate (3) weakly inhibited acetylcholinesterase (AChE). These results suggested that the effect of A. pennata on Alzheimer's disease was likely due to the inhibition of β-amyloid aggregation. Thus A. pennata may be beneficial for Alzheimer's prevention.