Publication: Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4α gene and insulin secretion index in Thais
Issued Date
2007-12-01
Resource Type
ISSN
14325233
09405429
09405429
Other identifier(s)
2-s2.0-36248989185
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Mahidol University
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SCOPUS
Bibliographic Citation
Acta Diabetologica. Vol.44, No.4 (2007), 227-232
Suggested Citation
W. Jongjaroenprasert, S. Chanprasertyothin, A. Kongsuksai, P. Bunnag, G. Puavilai, B. Ongphiphadhanakul Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4α gene and insulin secretion index in Thais. Acta Diabetologica. Vol.44, No.4 (2007), 227-232. doi:10.1007/s00592-007-0008-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24067
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Title
Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4α gene and insulin secretion index in Thais
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Abstract
This study was aimed to assess the association of the two single nucleotide polymorphisms (SNPs) near P2 promoter (rs1884614 and rs2144908) of hepatocyte nuclear factor-4α (HNF4A) with insulin secretion index and type 2 diabetes in Thais. Participants were categorized into three groups; unrelated type 2 diabetes (N = 219), prediabetes subjects (N = 228), and normal glucose tolerant controls (N = 203). Homeostasis model assessment was calculated for individual insulin secretion and insulin sensitivity index. Genotyping of both SNPs was done by allele-specific PCR technique. Difference of SNP allele frequencies between groups were computed using the χ2-statistic. Multivariate regression analysis was performed to determine the effect of SNPs on insulin secretion index. The clinical features of all groups were similar. We demonstrated genotype TT at rs1884614, BMI, and waist circumference were significantly associated with insulin secretion index (P = 0.023) but not with diabetes phenotype. © 2007 Springer-Verlag.