Calcium-phosphorus homeostasis in cats with spontaneous chronic kidney disease and metabolic acidosis

Abstract

The effect of metabolic acidosis on calcium-phosphorus homeostasis in cats with spontaneous chronic kidney disease (CKD) was studied. The cats were assigned into the clinically normal cats (n = 6), CKD (n = 9), and CKD with metabolic acidosis (12 cats). The CKD cats were cats with a blood urea nitrogen ≥50 mg/dl and creatinine level ≥2. 1 mg/dl. A complete blood count, sodium, potassium, total calcium, adjusted calcium, ionized calcium, phosphorus, parathyroid hormone, and vitamin D levels were measured. The cats with spontaneous CKD had a significantly lower hemoglobin and pack cell volume than the clinically normal cats. The CKD cats with metabolic acidosis had mean creatinine levels of 7. 12 ± 0. 76 mg/dl (severe azotemic stage) and significantly increased levels of parathyroid hormone and plasma phosphorus levels which indicated the presence of renal secondary hyperparathyroidism. © 2011 Springer-Verlag London Limited.