Publication: Admixture into and within sub-Saharan Africa
Issued Date
2016-06-21
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ISSN
2050084X
Other identifier(s)
2-s2.0-84975491862
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
eLife. Vol.5, No.JUN2016 (2016)
Suggested Citation
George B.J. Busby, Gavin Band, Quang Si Le, Muminatou Jallow, Edith Bougama, Valentina D. Mangano, Lucas N. Amenga-Etego, Anthony Enimil, Tobias Apinjoh, Carolyne M. Ndila, Alphaxard Manjurano, Vysaul Nyirongo, Ogobara Doumba, Kirk A. Rockett, Dominic P. Kwiatkowski, Chris C.A. Spencer, Aaron Vanderwal, Abier Elzein, Aceme Nyika, Alieu Mendy, Alistair Miles, Andrea Diss, Angeliki Kerasidou, Angie Green, Anna E. Jeffreys, Bronwyn MacInnis, Catherine Hughes, Catherine Moyes, Christina Hubbart, Cinzia Malangone, Claire Potter, Daniel Mead, David Barnwell, Dushyanth Jyothi, Eleanor Drury, Elilan Somaskantharajah, Eliza Hilton, Ellen Leffler, Gareth Maslen, George Busby, Geraldine M. Clarke, Ioannis Ragoussis, Jacob Almagro Garcia, Jane Rogers, Jantina deVries, Jennifer Shelton, Jiannis Ragoussis, Jim Stalker, Joanne Rodford, John O'Brien Admixture into and within sub-Saharan Africa. eLife. Vol.5, No.JUN2016 (2016). doi:10.7554/eLife.15266.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43005
Research Projects
Organizational Units
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Title
Admixture into and within sub-Saharan Africa
Author(s)
George B.J. Busby
Gavin Band
Quang Si Le
Muminatou Jallow
Edith Bougama
Valentina D. Mangano
Lucas N. Amenga-Etego
Anthony Enimil
Tobias Apinjoh
Carolyne M. Ndila
Alphaxard Manjurano
Vysaul Nyirongo
Ogobara Doumba
Kirk A. Rockett
Dominic P. Kwiatkowski
Chris C.A. Spencer
Aaron Vanderwal
Abier Elzein
Aceme Nyika
Alieu Mendy
Alistair Miles
Andrea Diss
Angeliki Kerasidou
Angie Green
Anna E. Jeffreys
Bronwyn MacInnis
Catherine Hughes
Catherine Moyes
Christina Hubbart
Cinzia Malangone
Claire Potter
Daniel Mead
David Barnwell
Dushyanth Jyothi
Eleanor Drury
Elilan Somaskantharajah
Eliza Hilton
Ellen Leffler
Gareth Maslen
George Busby
Geraldine M. Clarke
Ioannis Ragoussis
Jacob Almagro Garcia
Jane Rogers
Jantina deVries
Jennifer Shelton
Jiannis Ragoussis
Jim Stalker
Joanne Rodford
John O'Brien
Gavin Band
Quang Si Le
Muminatou Jallow
Edith Bougama
Valentina D. Mangano
Lucas N. Amenga-Etego
Anthony Enimil
Tobias Apinjoh
Carolyne M. Ndila
Alphaxard Manjurano
Vysaul Nyirongo
Ogobara Doumba
Kirk A. Rockett
Dominic P. Kwiatkowski
Chris C.A. Spencer
Aaron Vanderwal
Abier Elzein
Aceme Nyika
Alieu Mendy
Alistair Miles
Andrea Diss
Angeliki Kerasidou
Angie Green
Anna E. Jeffreys
Bronwyn MacInnis
Catherine Hughes
Catherine Moyes
Christina Hubbart
Cinzia Malangone
Claire Potter
Daniel Mead
David Barnwell
Dushyanth Jyothi
Eleanor Drury
Elilan Somaskantharajah
Eliza Hilton
Ellen Leffler
Gareth Maslen
George Busby
Geraldine M. Clarke
Ioannis Ragoussis
Jacob Almagro Garcia
Jane Rogers
Jantina deVries
Jennifer Shelton
Jiannis Ragoussis
Jim Stalker
Joanne Rodford
John O'Brien
Other Contributor(s)
Wellcome Trust Centre for Human Genetics
Wellcome Trust Sanger Institute
Medical Research Council Unit
Royal Victoria Teaching Hospital Gambia
Centre National de Recherche et de Formation sur le Paludisme
Università degli Studi di Roma La Sapienza
Navrongo Health Research Center
Komfo Anokye Teaching Hospital
University of Buea
Wellcome Trust Research Laboratories Nairobi
Kilimanjaro Christian Medical College
London School of Hygiene & Tropical Medicine
University of Malawi College of Medicine
University of Bamako
National Institute for Biological Standards and Control
Wellcome Trust
Bernhard Nocht Institut fur Tropenmedizin Hamburg
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases
Foundation for the National Institutes of Health
Institut Pasteur de Dakar
Institut Pasteur, Paris
Medical Research Council Laboratories Gambia
University of Ghana
Kwame Nkrumah University of Science and Technology
Wellcome Trust Sanger Institute
Medical Research Council Unit
Royal Victoria Teaching Hospital Gambia
Centre National de Recherche et de Formation sur le Paludisme
Università degli Studi di Roma La Sapienza
Navrongo Health Research Center
Komfo Anokye Teaching Hospital
University of Buea
Wellcome Trust Research Laboratories Nairobi
Kilimanjaro Christian Medical College
London School of Hygiene & Tropical Medicine
University of Malawi College of Medicine
University of Bamako
National Institute for Biological Standards and Control
Wellcome Trust
Bernhard Nocht Institut fur Tropenmedizin Hamburg
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases
Foundation for the National Institutes of Health
Institut Pasteur de Dakar
Institut Pasteur, Paris
Medical Research Council Laboratories Gambia
University of Ghana
Kwame Nkrumah University of Science and Technology
Abstract
© Busby et al. Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.