Publication: Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis
Issued Date
2015
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
European Journal of Medical Research. Vol. 20, (2015), 24
Suggested Citation
Jatupon Kongtharvonskul, Thunyarat Anothaisintawee, McEvoy, Mark, Attia, John, Patarawan Woratanarat, Ammarin Thakkinstian Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis. European Journal of Medical Research. Vol. 20, (2015), 24. doi:10.1186/s40001-015-0115-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2710
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis
Abstract
Background: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with
the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario
and McMaster Universities Osteoarthritis index (WOMAC) scores, Lequesne algofunctional index, joint space width
change, and adverse events) between diacerein, glucosamine, and placebo.
Methods: Medline and Scopus databases were searched from inception to 29 August 2014, using PubMed and
Scopus search engines and included RCTs or quasi-experimental designs comparing clinical outcomes between
treatments. Data were extracted from original studies. A network meta-analysis was performed by applying weight
regression for continuous outcomes and a mixed-effect Poisson regression for dichotomous outcomes.
Results: Thirty-one of 505 identified studies were eligible. Compared to placebo, glucosamine showed a significant
improvement with unstandardized mean differences (UMD) in total WOMAC, pain WOMAC, function WOMAC,
and Lequesne score of −2.49 (95% confidence interval (CI) −4.14, −0.83), −0.75 (95% CI: −1.18, −0.32), −4.78
(95% CI: −5.96, −3.59), and −1.03 (95% CI: −1.34, −0.72), respectively. Diacerein clinically improves visual analog
scores, function WOMAC, and stiffness WOMAC with UMD values of −2.23 (95% CI: −2.82, −1.64), −6.64 (95%
CI: −10.50, −2.78), and −0.68 (95% CI: −1.20, −0.16) when compared to placebo.
Conclusions: The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom
relief in knee OA, but that the former has more side effects.