Publication: Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
Issued Date
2013-02-01
Resource Type
ISSN
13475223
00092363
00092363
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2-s2.0-84873593744
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemical and Pharmaceutical Bulletin. Vol.61, No.2 (2013), 194-203
Suggested Citation
Pichit Sudta, Payung Jiarawapi, Apichart Suksamrarn, Poonpilas Hongmanee, Sunit Suksamrarn Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs. Chemical and Pharmaceutical Bulletin. Vol.61, No.2 (2013), 194-203. doi:10.1248/cpb.c12-00874 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31554
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Title
Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
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Abstract
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan.