Publication: Response of patients with bleeding disorder to DDAVP administration.
Issued Date
1993-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0027903368
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.24 Suppl 1, (1993), 174-179
Suggested Citation
A. Chuansumrit, P. Hathirat, P. Pintadit, P. Isarangkura Response of patients with bleeding disorder to DDAVP administration.. The Southeast Asian journal of tropical medicine and public health. Vol.24 Suppl 1, (1993), 174-179. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22647
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Title
Response of patients with bleeding disorder to DDAVP administration.
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Abstract
DDAVP has been shown to provide hemostasis in patients with bleeding disorder. Thirty-one episodes of intravenous DDAVP administration (0.3-0.4 microgram/kg) in 22 patients with bleeding disorder were studied. There were 13 patients with hemophilia A, 1 with type I vWD and 8 with inherited and acquired platelet dysfunction. The age ranged from 2.3-26 yrs (mean +/- SD = 10 +/- 4.8). None of the 3 severe hemophilia A patients responded to the treatment. Two out of five episodes in 4 moderate hemophilia A patients responded clinically and had minute increments of F VIII:C. Ten out of eleven episodes (91%) in 6 mild hemophilia A patients had good responses. The dental procedures for these patients were successfully performed without blood component transfusion. The increments of F VIII:C ranged from 1.5-6.8 folds over the baseline levels (mean +/- SD = 2.5 +/- 1.4). In addition, two episodes of epistaxis in a vWD patient responded excellently and one dental procedure was successfully performed by giving DDAVP. The increments of F VIII:C and vWF:Ag ranged from 2.8-12.5 and 2.9-8 fold over the baseline levels respectively. The prolonged bleeding times were shorten to 6.5-7 minutes. Only three out of eight episodes in 8 inherited and acquired platelet dysfunction patients showed temporary responses. The bleeding time responses did not correlate with in vitro platelet aggregation.