Publication: Long-term virological outcomes of first-line antiretroviral therapy for HIV-1 in low- and middle-income countries: A systematic review and meta-analysis
Issued Date
2015-11-01
Resource Type
ISSN
15376591
10584838
10584838
Other identifier(s)
2-s2.0-84946731866
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Infectious Diseases. Vol.61, No.9 (2015), 1453-1461
Suggested Citation
T. Sonia Boender, Kim C.E. Sigaloff, James H. Mcmahon, Sasisopin Kiertiburanakul, Michael R. Jordan, Jhoney Barcarolo, Nathan Ford, Tobias F. Rinke De Wit, Silvia Bertagnolio Long-term virological outcomes of first-line antiretroviral therapy for HIV-1 in low- and middle-income countries: A systematic review and meta-analysis. Clinical Infectious Diseases. Vol.61, No.9 (2015), 1453-1461. doi:10.1093/cid/civ556 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36277
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Title
Long-term virological outcomes of first-line antiretroviral therapy for HIV-1 in low- and middle-income countries: A systematic review and meta-analysis
Abstract
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. Background.More than 11.7 million people are currently receiving antiretroviral therapy (ART) in low- and middle-income countries (LMICs), and focused efforts are needed to ensure high levels of adherence and to minimize treatment failure. Recently, international targets have emphasized the importance of long-term virological suppression as a key measure of program performance. Methods.We systematically reviewed publications and conference abstracts published between January 2006 and May 2013 that reported virological outcomes among human immunodeficiency virus type 1 (HIV-1)-infected adults receiving first-line ART for up to 5 years in LMICs. Summary estimates of virological suppression after 6, 12, 24, 36, 48, and 60 months of ART were analyzed using random-effects meta-analysis. Intention-to-treat (ITT) analysis assumed all participants who were lost to follow-up, died, or stopped ART as having virological failure. Results.Summary estimates of virological suppression remained >80% for up to 60 months of ART for all 184 included cohorts. ITT analysis yielded 74.7% (95% confidence interval [CI], 72.2-77.2) suppression after 6 months and 61.8% (95% CI, 44.0-79.7) suppression after 48 months on ART. Switches to second-line ART were reported scarcely. Conclusions.Among individuals retained on ART, virological suppression rates during the first 5 years of ART were high (>80%) and stable. Suppression rates in ITT analysis declined during 4 years.