Publication: HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX ® B/E
Issued Date
2012-01-20
Resource Type
ISSN
18732518
0264410X
0264410X
Other identifier(s)
2-s2.0-84855439087
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.30, No.5 (2012), 832-836
Suggested Citation
Robert Paris, Sasitorn Bejrachandra, Prasert Thongcharoen, Sorachai Nitayaphan, Punnee Pitisuttithum, Anna Sambor, Sanjay Gurunathan, Donald Francis, Silvia Ratto-Kim, Chitraporn Karnasuta, Mark S. de Souza, Victoria R. Polonis, Arthur E. Brown, Jerome H. Kim, Henry A. Stephens HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX ® B/E. Vaccine. Vol.30, No.5 (2012), 832-836. doi:10.1016/j.vaccine.2011.11.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13823
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Title
HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX ® B/E
Other Contributor(s)
Armed Forces Research Institute of Medical Sciences, Thailand
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
United States Military HIV Research Program/Henry M. Jackson Foundation
Sanofi Pasteur
Global Solutions for Infectious Diseases
Walter Reed Army Institute of Research
UCL
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
United States Military HIV Research Program/Henry M. Jackson Foundation
Sanofi Pasteur
Global Solutions for Infectious Diseases
Walter Reed Army Institute of Research
UCL
Abstract
Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE. Non-response to vaccine associated with DRB1*11 (3/32 responders vs. 7/13 non-responders, p c =0.027) and DRB1*16:02 (0/32 responders vs. 4/13 non-responders, p c =0.078) alleles. Furthermore, vaccine recipients with HLA-DQ heterodimers encoded by DQA1*05:01 and DQB1*03:01 alleles, were much less likely to produce NAb (p=0.009). These data suggest that the lack of response to a vaccine designed to induce clade-specific NAb to HIV-1 is associated with the presence of certain HLA class II alleles and heterodimers in some Southeast Asians. © 2011.