Publication:
A single-nucleotide substitution from C to T at position - 1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

Issued Date

2003-10-01

Resource Type

Article

ISSN

14664879

DOI

10.1038/sj.gene.6364010

Other identifier(s)

2-s2.0-3242745930

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Genes and Immunity. Vol.4, No.7 (2003), 528-531

Suggested Citation

Juno Ohashi, I. Naka, J. Patarapotikul, H. Hananantachai, S. Looareesuwan, K. Tokunaga A single-nucleotide substitution from C to T at position - 1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. Genes and Immunity. Vol.4, No.7 (2003), 528-531. doi:10.1038/sj.gene.6364010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20689

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Title

A single-nucleotide substitution from C to T at position - 1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

Author(s)

Juno Ohashi
 I. Naka
 J. Patarapotikul
 H. Hananantachai
 S. Looareesuwan
 K. Tokunaga

Other Contributor(s)

University of Tokyo
 Mahidol University

Abstract

We examined possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL- 13 genes on the 5q31-33, IL-3 - 16T> C, IL-4 - 590T> C, and IL-13 - 1055C> T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 - 1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P= 0.0032 by the χ2test), while allele frequencies of IL-3 - 16T> C and IL-4 -590T> C were not statistically different between mild and severe malaria patients. An IL-13 - 1055C> T has been reported to alter the regulation of IL-13 production. Thus, IL-13 - 1055T may show resistance to severe malaria through the alteration of IL-13 production. © 2003 Nature Publishing Group All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20689

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Scopus 2001-2005