Publication:
Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates

Issued Date

2018-12-01

Resource Type

Article

ISSN

20452322

DOI

10.1038/s41598-018-29986-3

Other identifier(s)

2-s2.0-85051061432

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Scientific Reports. Vol.8, No.1 (2018)

Suggested Citation

Prasit Palittapongarnpim, Pravech Ajawatanawong, Wasna Viratyosin, Nat Smittipat, Areeya Disratthakit, Surakameth Mahasirimongkol, Hideki Yanai, Norio Yamada, Supalert Nedsuwan, Worarat Imasanguan, Pacharee Kantipong, Boonchai Chaiyasirinroje, Jiraporn Wongyai, Licht Toyo-oka, Jody Phelan, Julian Parkhill, Taane G. Clark, Martin L. Hibberd, Wuthiwat Ruengchai, Panawun Palittapongarnpim, Tada Juthayothin, Sissades Tongsima, Katsushi Tokunaga Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates. Scientific Reports. Vol.8, No.1 (2018). doi:10.1038/s41598-018-29986-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47499

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Title

Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates

Author(s)

Prasit Palittapongarnpim
 Pravech Ajawatanawong
 Wasna Viratyosin
 Nat Smittipat
 Areeya Disratthakit
 Surakameth Mahasirimongkol
 Hideki Yanai
 Norio Yamada
 Supalert Nedsuwan
 Worarat Imasanguan
 Pacharee Kantipong
 Boonchai Chaiyasirinroje
 Jiraporn Wongyai
 Licht Toyo-oka
 Jody Phelan
 Julian Parkhill
 Taane G. Clark
 Martin L. Hibberd
 Wuthiwat Ruengchai
 Panawun Palittapongarnpim
 Tada Juthayothin
 Sissades Tongsima
 Katsushi Tokunaga

Other Contributor(s)

Japan Anti-Tuberculosis Association
 London School of Hygiene & Tropical Medicine
 University of Tokyo
 Thailand Ministry of Public Health
 Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology
 The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
 Wellcome Sanger Institute
 TB/HIV Research Foundation

Abstract

© 2018, The Author(s). Tuberculosis presents a global health challenge. Mycobacterium tuberculosis is divided into several lineages, each with a different geographical distribution. M. tuberculosis lineage 1 (L1) is common in the high-burden areas in East Africa and Southeast Asia. Although the founder effect contributes significantly to the phylogeographic profile, co-evolution between the host and M. tuberculosis may also play a role. Here, we reported the genomic analysis of 480 L1 isolates from patients in northern Thailand. The studied bacterial population was genetically diverse, allowing the identification of a total of 18 sublineages distributed into three major clades. The majority of isolates belonged to L1.1 followed by L1.2.1 and L1.2.2. Comparison of the single nucleotide variant (SNV) phylogenetic tree and the clades defined by spoligotyping revealed some monophyletic clades representing EAI2_MNL, EAI2_NTM and EAI6_BGD1 spoligotypes. Our work demonstrates that ambiguity in spoligotype assignment could be partially resolved if the entire DR region is investigated. Using the information to map L1 diversity across Southeast Asia highlighted differences in the dominant strain-types in each individual country, despite extensive interactions between populations over time. This finding supported the hypothesis that there is co-evolution between the bacteria and the host, and have implications for tuberculosis disease control.

Keyword(s)

Multidisciplinary

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/47499

Collections

Scopus 2018