Publication: R147W in PROC Gene Is a Risk Factor of Thromboembolism in Thai Children
Issued Date
2018-03-01
Resource Type
ISSN
19382723
10760296
10760296
Other identifier(s)
2-s2.0-85041324222
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and Applied Thrombosis/Hemostasis. Vol.24, No.2 (2018), 263-267
Suggested Citation
Nongnuch Sirachainan, Ampaiwan Chuansumrit, Werasak Sasanakul, Najwa Yudhasompop, Lalita Mahaklan, Jarin Vaewpanich, Pimlak Charoenkwan, Somjai Kanjanapongkul, Anannit Visudtibhan, Pakawan Wongwerawattanakoon R147W in PROC Gene Is a Risk Factor of Thromboembolism in Thai Children. Clinical and Applied Thrombosis/Hemostasis. Vol.24, No.2 (2018), 263-267. doi:10.1177/1076029617709085 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46914
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
R147W in PROC Gene Is a Risk Factor of Thromboembolism in Thai Children
Abstract
© 2017, © The Author(s) 2017. The p.R147W mutation, the c.C6152T in exon 7, causing a change in amino acid from arginine to tryptophan of the PROC gene has been reported as a common mutation in Taiwanese populations with venous thromboembolism (VTE). The present study aimed to identify the prevalence of p.R147W in the Thai population and children with TE and the risk of developing TE. Patients aged ≤18 years diagnosed with TE were enrolled. The PROC gene was amplified by polymerase chain reaction using a specific primer in exon 7. The restriction fragment length polymorphism was designed using MwoI restriction enzyme. A total of 184 patients and 690 controls were enrolled. The most common diagnosis of TE was arterial ischemic stroke (AIS), at 100 (54.3%), followed by VTE, at 38 (20.6%), and cerebral venous sinus thrombosis (CVST), at 23 (12.5%). The prevalence of heterozygous and homozygous p.R147W in patients and controls was 9.5% versus 5.8% and 2.7% versus 0.1%, respectively. Heterozygous p.R147W had odds ratios (ORs) of 1.8 (95% confidence interval [CI]: 1.0-3.2, P =.04), 3.2 (95% CI: 1.2-8.2, P =.009), and 4.5 (95% CI: 1.6-12.8, P =.002) of developing overall TE, VTE, and CVST, respectively. Homozygous p.R147W had ORs of 20.2 (95% CI: 2.3-173.7, P <.001), 21.4 (95% CI: 2.2-207.9, P <.001), and 43.3 (95% CI: 3.8-490.6, P <.001) of developing overall TE, AIS, and CVST, respectively. This study suggested that p.R147W is a common mutation and increased risk of TE in Thai children.