Publication:
Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells

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dc.contributor.authorKanitsak Boonanantanasarnen_US
dc.contributor.authorKajohnkiart Janebodinen_US
dc.contributor.authorPrapan Suppakpatanaen_US
dc.contributor.authorTawepong Arayapisiten_US
dc.contributor.authorJit aree Rodsutthien_US
dc.contributor.authorPanjit Chunhabunditen_US
dc.contributor.authorSurintorn Boonanuntanasarnen_US
dc.contributor.authorWanida Sripairojthikoonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity at Buffalo, State University of New Yorken_US
dc.contributor.otherSuranaree University of Technologyen_US
dc.date.accessioned2018-06-11T04:46:13Z
dc.date.available2018-06-11T04:46:13Z
dc.date.issued2012-10-30en_US
dc.description.abstractThis present study investigated the potential of Morinda citrifolia leaf aqueous extract to induce osteogenic differentiation and matrix mineralization of human periodontal ligament (hPDL) cells. Human periodontal ligament cells were cultured in complete medium, ascorbic acid with β-glycerophosphate, or Morinda citrifolia leaf aqueous extract. Morinda citrifolia leaf aqueous extract significantly increased alkaline phosphatase activity compared to culturing in complete medium or ascorbic acid with β-glycerophosphate. Matrixcontaining mineralized nodules were formed only when the cells were cultured in the presence of Morinda citrifolia leaf aqueous extract. These nodules showed positive alizarin red S staining and were rich in calcium and phosphorus according to energy dispersive X-ray analysis. In conclusion, Morinda citrifolia leaf extract promoted osteogenic differentiation and matrix mineralization in human periodontal ligament cells, a clear indication of the therapeutic potential of Morinda citrifolia leaves in bone and periodontal tissue regeneration.en_US
dc.identifier.citationDental Materials Journal. Vol.31, No.5 (2012), 863-871en_US
dc.identifier.doi10.4012/dmj.2012-053en_US
dc.identifier.issn18811361en_US
dc.identifier.issn02874547en_US
dc.identifier.other2-s2.0-84867861374en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/14073
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867861374&origin=inwarden_US
dc.subjectDentistryen_US
dc.subjectMaterials Scienceen_US
dc.titleMorinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867861374&origin=inwarden_US

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