Publication:
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study

Issued Date

2021-05-01

Resource Type

Article

ISSN

17582652

DOI

10.1002/jia2.25736

Other identifier(s)

2-s2.0-85106697623

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of the International AIDS Society. Vol.24, No.5 (2021)

Suggested Citation

Win Min Han, Awachana Jiamsakul, Nur Afiqah Mohd Salleh, Jun Yong Choi, Bui Vu Huy, Evy Yunihastuti, Cuong Duy Do, Tuti P. Merati, Yasmin M. Gani, Sasisopin Kiertiburanakul, Fujie Zhang, Yu Jiun Chan, Man Po Lee, Romanee Chaiwarith, Oon Tek Ng, Suwimon Khusuwan, Rossana Ditangco, Nagalingeswaran Kumarasamy, Shashikala Sangle, Jeremy Ross, Anchalee Avihingsanon, P. S. Ly, V. Khol, F. J. Zhang, H. X. Zhao, N. Han, M. P. Lee, P. C.K. Li, W. Lam, Y. T. Chan, C. Ezhilarasi, S. Pujari, K. Joshi, S. Gaikwad, A. Chitalikar, V. Mave, I. Marbaniang, S. Nimkar, D. N. Wirawan, F. Yuliana, A. Widhani, S. Maria, T. H. Karjadi, J. Tanuma, S. Oka, T. Nishijima, J. Y. Choi, S. Na, J. M. Kim, N. B. Rudi, I. Azwa, A. Kamarulzaman, S. F. Syed Omar, S. Ponnampalavanar, M. K. Pasayan, M. L. Mationg, W. W. Ku, P. C. Wu, E. Ke, P. L. Lim, L. S. Lee, D. Liang, A. Avihingsanon, S. Gatechompol, P. Phanuphak, C. Phadungphon, A. Phuphuakrat, L. Chumla, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, J. Praparattanapan, K. Nuket, P. Kantipong, P. Kambua, K. V. Nguyen, H. V. Bui, D. T.H. Nguyen, D. T. Nguyen, C. D. Do, A. V. Ngo, L. T. Nguyen, A. H. Sohn, B. Petersen, M. G. Law, R. Bijker, D. Rupasinghe HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study. Journal of the International AIDS Society. Vol.24, No.5 (2021). doi:10.1002/jia2.25736 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78225

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Journal Issue

Thesis

Title

HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study

Author(s)

Win Min Han
 Awachana Jiamsakul
 Nur Afiqah Mohd Salleh
 Jun Yong Choi
 Bui Vu Huy
 Evy Yunihastuti
 Cuong Duy Do
 Tuti P. Merati
 Yasmin M. Gani
 Sasisopin Kiertiburanakul
 Fujie Zhang
 Yu Jiun Chan
 Man Po Lee
 Romanee Chaiwarith
 Oon Tek Ng
 Suwimon Khusuwan
 Rossana Ditangco
 Nagalingeswaran Kumarasamy
 Shashikala Sangle
 Jeremy Ross
 Anchalee Avihingsanon
 P. S. Ly
 V. Khol
 F. J. Zhang
 H. X. Zhao
 N. Han
 M. P. Lee
 P. C.K. Li
 W. Lam
 Y. T. Chan
 C. Ezhilarasi
 S. Pujari
 K. Joshi
 S. Gaikwad
 A. Chitalikar
 V. Mave
 I. Marbaniang
 S. Nimkar
 D. N. Wirawan
 F. Yuliana
 A. Widhani
 S. Maria
 T. H. Karjadi
 J. Tanuma
 S. Oka
 T. Nishijima
 J. Y. Choi
 S. Na
 J. M. Kim
 N. B. Rudi
 I. Azwa
 A. Kamarulzaman
 S. F. Syed Omar
 S. Ponnampalavanar
 M. K. Pasayan
 M. L. Mationg
 W. W. Ku
 P. C. Wu
 E. Ke
 P. L. Lim
 L. S. Lee
 D. Liang
 A. Avihingsanon
 S. Gatechompol
 P. Phanuphak
 C. Phadungphon
 A. Phuphuakrat
 L. Chumla
 N. Sanmeema
 R. Chaiwarith
 T. Sirisanthana
 J. Praparattanapan
 K. Nuket
 P. Kantipong
 P. Kambua
 K. V. Nguyen
 H. V. Bui
 D. T.H. Nguyen
 D. T. Nguyen
 C. D. Do
 A. V. Ngo
 L. T. Nguyen
 A. H. Sohn
 B. Petersen
 M. G. Law
 R. Bijker
 D. Rupasinghe

Other Contributor(s)

Hospital Sungai Buloh
 Beijing Ditan Hospital Capital Medical University
 VHS Medical Centre India
 Gokila
 Bach Mai Hospital
 Universitas Udayana
 Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Thai Red Cross Agency
 Universiti Malaya
 Chulalongkorn University
 The Kirby Institute
 National Center for Global Health and Medicine
 The HIV Netherlands Australia Thailand Research Collaboration
 Yonsei University College of Medicine
 Faculty of Medicine Ramathibodi Hospital, Mahidol University
 Queen Elizabeth Hospital Hong Kong
 University of Malaya Medical Centre
 Veterans General Hospital-Taipei
 Tan Tock Seng Hospital
 BJ Government Medical College and Sassoon General Hospital
 National Hospital for Tropical Diseases
 amfAR - The Foundation for AIDS Research
 Institute of Infectious Diseases
 Chiangrai Prachanukroh Hospital
 National Center for HIV/AIDS
 Research Institute for Health Sciences

Abstract

INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/78225

Collections

Scopus 2021