Publication: Midazolam-flumazenil topical anaesthesia for microlaryngoscopy with jet ventilation
Issued Date
1997-08-01
Resource Type
ISSN
0310057X
Other identifier(s)
2-s2.0-0030862863
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Mahidol University
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SCOPUS
Bibliographic Citation
Anaesthesia and Intensive Care. Vol.25, No.4 (1997), 358-364
Suggested Citation
W. Rushatamukayanunt, T. Tritrakarn Midazolam-flumazenil topical anaesthesia for microlaryngoscopy with jet ventilation. Anaesthesia and Intensive Care. Vol.25, No.4 (1997), 358-364. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18108
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Title
Midazolam-flumazenil topical anaesthesia for microlaryngoscopy with jet ventilation
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Abstract
A comparison between midazolam and midazolam-flumazenil for total intravenous anaesthesia in combination with topical anaesthesia and muscle relaxants was performed in a double-blind, parallel study in 40 patients scheduled for microlaryngoscopy with or without bronchoscopic procedures using jet ventilation with oxygen. A single intravenous injection of midazolam 0.3 mg/kg, lignocaine spray and muscle relaxants provided adequate anaesthesia and good operative conditions throughout the procedures, which took 20 to 30 minutes. Patients who had placebo at the end of the procedures had a longer recovery and a high incidence of airway obstruction (20%). Administration of flumazenil provided prompt awakening in 19 of 20 patients (95%) within five minutes, resulting in rapid and favourable recover without resedation or other side-effects, while only three of 20 (15%) patients in the placebo-treated group had improved consciousness within five minutes. The simplicity and reliability of the midazolam-flumazenil technique is attractive. We consider it worthy of further investigation for wider application in clinical practice.