Publication: X-treme loss of sequence diversity linked to neo-x chromosomes in filarial nematodes
Issued Date
2021-10-01
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ISSN
19352735
19352727
19352727
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2-s2.0-85118947984
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Mahidol University
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SCOPUS
Bibliographic Citation
PLoS Neglected Tropical Diseases. Vol.15, No.10 (2021)
Suggested Citation
John Mattick, Silvia Libro, Robin Bromley, Wanpen Chaicumpa, Matthew Chung, Darren Cook, Mohammad Behram Khan, Nikhil Kumar, Yeeling Lau, Shailja Misra-Bhattacharya, Ramakrishna Rao, Lisa Sadzewicz, Atiporn Saeung, Mohd Shahab, Benjamin C. Sparklin, Andrew Steven, Joseph D. Turner, Luke J. Tallon, Mark J. Taylor, Andrew R. Moorhead, Michelle Michalski, Jeremy M. Foster, Julie C.Dunning Hotopp X-treme loss of sequence diversity linked to neo-x chromosomes in filarial nematodes. PLoS Neglected Tropical Diseases. Vol.15, No.10 (2021). doi:10.1371/journal.pntd.0009838 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77783
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Title
X-treme loss of sequence diversity linked to neo-x chromosomes in filarial nematodes
Author(s)
John Mattick
Silvia Libro
Robin Bromley
Wanpen Chaicumpa
Matthew Chung
Darren Cook
Mohammad Behram Khan
Nikhil Kumar
Yeeling Lau
Shailja Misra-Bhattacharya
Ramakrishna Rao
Lisa Sadzewicz
Atiporn Saeung
Mohd Shahab
Benjamin C. Sparklin
Andrew Steven
Joseph D. Turner
Luke J. Tallon
Mark J. Taylor
Andrew R. Moorhead
Michelle Michalski
Jeremy M. Foster
Julie C.Dunning Hotopp
Silvia Libro
Robin Bromley
Wanpen Chaicumpa
Matthew Chung
Darren Cook
Mohammad Behram Khan
Nikhil Kumar
Yeeling Lau
Shailja Misra-Bhattacharya
Ramakrishna Rao
Lisa Sadzewicz
Atiporn Saeung
Mohd Shahab
Benjamin C. Sparklin
Andrew Steven
Joseph D. Turner
Luke J. Tallon
Mark J. Taylor
Andrew R. Moorhead
Michelle Michalski
Jeremy M. Foster
Julie C.Dunning Hotopp
Other Contributor(s)
Siriraj Hospital
Central Drug Research Institute India
University of Georgia
Universiti Malaya
University of Wisconsin Oshkosh
New England Biolabs
Washington University School of Medicine in St. Louis
Liverpool School of Tropical Medicine
University of Maryland, Baltimore (UMB)
Chiang Mai University
Central Drug Research Institute India
University of Georgia
Universiti Malaya
University of Wisconsin Oshkosh
New England Biolabs
Washington University School of Medicine in St. Louis
Liverpool School of Tropical Medicine
University of Maryland, Baltimore (UMB)
Chiang Mai University
Abstract
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (πX/ πA = 0.2), which is lower than the expected (πX/πA = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria, but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria. In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.