Publication: Interactions between developing nerves and salivary glands
Issued Date
2013-01-01
Resource Type
ISSN
15558592
15476278
15476278
Other identifier(s)
2-s2.0-84883010764
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Organogenesis. Vol.9, No.3 (2013), 152-158
Suggested Citation
João N. Ferreira, Matthew P. Hoffman Interactions between developing nerves and salivary glands. Organogenesis. Vol.9, No.3 (2013), 152-158. doi:10.4161/org.25224 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31402
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Interactions between developing nerves and salivary glands
Author(s)
Other Contributor(s)
Abstract
Our aim is to provide a summary of the field of salivary gland development and regeneration from the perspective of what is known about the function of nerves during these processes. The primary function of adult salivary glands is to produce and secrete saliva. Neuronal control of adult salivary gland function has been a focus of research ever since Pavlov's seminal experiments on salivation in dogs. Less is known about salivary gland innervation during development and how the developing nerves influence gland organogenesis and regeneration. Here, we will review what is known about the communication between the autonomic nervous system and the epithelium of the salivary glands during organogenesis. An important emerging theme is the instructive role of the nervous system on the epithelial stem/progenitor cells during development as well as regeneration after damage. We will provide a brief overview of the neuroanatomy of the salivary glands and discuss recent literature that begins to integrate neurobiology with epithelial organogenesis, which may provide paradigms for exploring these interactions in other organ systems. © 2013 Landes Bioscience.