Publication:
Hemagglutinin codon optimization: a promising tool for enhancing the immunogenicity of influenza virus vaccines

Issued Date

2014-01-01

Resource Type

Review

ISSN

1934841X
08914168

DOI

10.3103/S089141681404003X

Other identifier(s)

2-s2.0-84961358603

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Molecular Genetics, Microbiology and Virology. Vol.29, No.4 (2014), 159-166

Suggested Citation

E. A. Fedorova, I. V. Kiseleva, P. Auewarakul, O. Suptawiwat, L. G. Rudenko Hemagglutinin codon optimization: a promising tool for enhancing the immunogenicity of influenza virus vaccines. Molecular Genetics, Microbiology and Virology. Vol.29, No.4 (2014), 159-166. doi:10.3103/S089141681404003X Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33472

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Title

Hemagglutinin codon optimization: a promising tool for enhancing the immunogenicity of influenza virus vaccines

Author(s)

E. A. Fedorova
 I. V. Kiseleva
 P. Auewarakul
 O. Suptawiwat
 L. G. Rudenko

Other Contributor(s)

Institute of Experimental Medicine, Russian Academy of Medical Sciences
 Mahidol University

Abstract

© 2014, Allerton Press, Inc. Modification of the codon bias of gene sequences is a promising tool of gene expression control. This review presents the theoretical basis of the codon optimization and summarizes the published data on experimental modification of the codon bias of viral genes for the purposes of vaccine development. Studies aimed at enhancing the immunogenicity of influenza vaccines by means of codon optimization are discussed in detail. The prospects of applying the codon optimization technique for the development of influenza vaccines are analyzed.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/33472

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Scopus 2011-2015