Publication: Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum
Issued Date
2004-01-01
Resource Type
ISSN
14726483
Other identifier(s)
2-s2.0-4544269261
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Mahidol University
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SCOPUS
Bibliographic Citation
Reproductive BioMedicine Online. Vol.9, No.3 (2004), 264-270
Suggested Citation
S. Sangchai Preutthipan, S. H. Chen, J. L. Tilly, K. Kugu, R. R. Lareu, A. M. Dharmarajan Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum. Reproductive BioMedicine Online. Vol.9, No.3 (2004), 264-270. doi:10.1016/S1472-6483(10)62140-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21250
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Title
Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum
Abstract
To determine if nitric oxide (NO) plays a role in corpus luteum (CL) physiology by affecting progesterone secretion or luteal apoptosis, an in-vitro pseudopregnant rabbit ovarian perfusion system was used to measure the effects of an inhibitor of NO synthesis, NG-nitro-L-arginine methyl ester (L-NAME), on progesterone secretion and corpus luteal apoptosis as measured by internucleosomal DNA breakdown. Pseudopregnant rabbit ovaries perfused in vitro with L-NAME did not demonstrate any significant differences compared with control ovaries in progesterone secretion. However, apoptosis, as measured by internucleosomal breakdown, was significantly increased in L-NAME-perfused CL compared with controls. While NO does not appear to directly affect progesterone secretion, there does appear to be a role for NO in CL maintenance, or a role for inhibition of NO production in CL regression.