Publication: <sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells
Issued Date
1993-01-01
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ISSN
15206025
01633864
01633864
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2-s2.0-0027551488
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.56, No.2 (1993), 233-239
Suggested Citation
Aimon Somanabandhu, Siriporn Nitayangkura, Chulabhorn Mahidol, Somsak Ruchirawat, Kittisak Likhitwitayawuid, Hui Ling Shieh, Heebyung Chai, John M. Pezzuto, Geoffrey A. Cordell <sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. Journal of Natural Products. Vol.56, No.2 (1993), 233-239. doi:10.1021/np50092a008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22554
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Title
<sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells
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Abstract
Complete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin [1] and hypophyllanthin [2] were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin [2] was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein. © 1993, American Chemical Society. All rights reserved.