Publication: Gastric mucosal lesions in streptozotocin-diabetic rats
Issued Date
1988-01-01
Resource Type
ISSN
03091651
Other identifier(s)
2-s2.0-0023718031
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell Biology International Reports. Vol.12, No.1 (1988), 53-63
Suggested Citation
Pawinee Piyachaturawat, Jiranud Poprasit, Thirayudh Glinsukon, Chaitip Wanichanon Gastric mucosal lesions in streptozotocin-diabetic rats. Cell Biology International Reports. Vol.12, No.1 (1988), 53-63. doi:10.1016/0309-1651(88)90111-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15499
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Gastric mucosal lesions in streptozotocin-diabetic rats
Other Contributor(s)
Abstract
Formation of gastric mucosal lesions by streptozotocin-induced diabetes was investigated in rats. A single intraveous administration of streptozotocin in a dose of 65 mg/kg effectively produced hyperglycemia and damaged the gastric mucosa. Incidence and severity of mucosal lesions were progressively increased with time, from one to six weeks posttreatment. Microscopic lesions of the mucosa included hyperemia, desquamation of the surface epithelium with diffuse hemorrhage, and severe hemorrhage with localized erosion. Concurrent to the hyperglycemia, the histamine stimulated gastric H + -secretion was significantly decreased whereas pepsin secretion was not affected. Both soluble mucus and surface mucus gel were increased. The result suggests that the early lesion of gastric mucosa may be associated with the direct action of streptozotocin, the severity of which may be further aggravated by diabetic state. © 1988.