Publication:
Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey

Issued Date

2021-11-01

Resource Type

Article

ISSN

14354373
09349723

DOI

10.1007/s10096-021-04288-1

Other identifier(s)

2-s2.0-85117479837

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Clinical Microbiology and Infectious Diseases. Vol.40, No.11 (2021), 2323-2334

Suggested Citation

Rehab El-Sokkary, Serhat Uysal, Hakan Erdem, Ravina Kullar, Abdullah Umut Pekok, Fatma Amer, Svjetlana Grgić, Biljana Carevic, Amani El-Kholy, Anna Liskova, Mehmet Özdemir, Ejaz Ahmed Khan, Yesim Uygun-Kizmaz, Nenad Pandak, Nirav Pandya, Jurica Arapović, Rıdvan Karaali, Nefise Oztoprak, Michael M. Petrov, Rami Alabadla, Handan Alay, Jehan Ali El Kholy, Caroline Landelle, Reham Khedr, Dhruv Mamtora, Gorana Dragovac, Ricardo Fernandez, Emine Unal Evren, Lul Raka, Antonio Cascio, Nicolas Dauby, Ahsen Oncul, Safak Ozer Balin, Yasemin Cag, Natalia Dirani, Mustafa Dogan, Irina Magdalena Dumitru, Maha Ali Gad, Ilad Alavi Darazam, Behrouz Naghili, Rosa Fontana Del Vecchio, Monica Licker, Andrea Marino, Nasim Akhtar, Mostafa Kamal, Goffredo Angioni, Deana Medić, Aliye Esmaoğlu, Szabo Balint Gergely, André Silva-Pinto, Lurdes Santos, Ionela Larisa Miftode, Recep Tekin, Phunsup Wongsurakiat, Mumtaz Ali Khan, Yesim Kurekci, Hema Prakash Pilli, Krsto Grozdanovski, Egidia Miftode, Rusmir Baljic, Haluk Vahabolgu, Jordi Rello Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey. European Journal of Clinical Microbiology and Infectious Diseases. Vol.40, No.11 (2021), 2323-2334. doi:10.1007/s10096-021-04288-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77718

Research Projects

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Journal Issue

Thesis

Title

Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey

Author(s)

Rehab El-Sokkary
 Serhat Uysal
 Hakan Erdem
 Ravina Kullar
 Abdullah Umut Pekok
 Fatma Amer
 Svjetlana Grgić
 Biljana Carevic
 Amani El-Kholy
 Anna Liskova
 Mehmet Özdemir
 Ejaz Ahmed Khan
 Yesim Uygun-Kizmaz
 Nenad Pandak
 Nirav Pandya
 Jurica Arapović
 Rıdvan Karaali
 Nefise Oztoprak
 Michael M. Petrov
 Rami Alabadla
 Handan Alay
 Jehan Ali El Kholy
 Caroline Landelle
 Reham Khedr
 Dhruv Mamtora
 Gorana Dragovac
 Ricardo Fernandez
 Emine Unal Evren
 Lul Raka
 Antonio Cascio
 Nicolas Dauby
 Ahsen Oncul
 Safak Ozer Balin
 Yasemin Cag
 Natalia Dirani
 Mustafa Dogan
 Irina Magdalena Dumitru
 Maha Ali Gad
 Ilad Alavi Darazam
 Behrouz Naghili
 Rosa Fontana Del Vecchio
 Monica Licker
 Andrea Marino
 Nasim Akhtar
 Mostafa Kamal
 Goffredo Angioni
 Deana Medić
 Aliye Esmaoğlu
 Szabo Balint Gergely
 André Silva-Pinto
 Lurdes Santos
 Ionela Larisa Miftode
 Recep Tekin
 Phunsup Wongsurakiat
 Mumtaz Ali Khan
 Yesim Kurekci
 Hema Prakash Pilli
 Krsto Grozdanovski
 Egidia Miftode
 Rusmir Baljic
 Haluk Vahabolgu
 Jordi Rello

Other Contributor(s)

Shifa Tameer-e-Millat University
 Siriraj Hospital
 University of Health Sciences
 University of Kyrenia
 Children's Cancer Hospital 57357
 ATS Sardegna, ASSL Cagliari SS. Trinità
 Vall d'Hebron Institut de Recerca
 National Institute of Public Health of Kosovo
 University of Mostar
 Universite Grenoble Alpes
 Necmettin Erbakan Üniversitesi
 Istanbul Medeniyet University
 Bhailal Amin General Hospital
 Namik Kemal Üniversitesi
 Royal Hospital
 Klinicki Centar Srbije
 MEDICINSKI FAKULTET
 Pakistan Institute of Medical Sciences
 National Institute of Health Pakistan
 Medical University of Plovdiv
 Tabriz University of Medical Sciences
 Erciyes University, Faculty of Medicine
 Gandhi Institute of Technology and Management, Visakhapatnam
 Kasr El-Aini School of Medicine
 Ovidius University of Constanta
 Shahid Beheshti University of Medical Sciences
 Dicle University, Faculty of Medicine
 Università degli Studi di Palermo
 Universitatea de Medicina si Farmacie Victor Babes din Timisoara
 Ataturk University, Faculty of Medicine
 Zagazig University, Faculty of Medicine
 İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
 Università degli Studi di Catania
 Firat Üniversitesi Tip Fakültesi
 Université Libre de Bruxelles
 South-Pest Central Hospital
 St. Elisabeth University of Health Care and Social Work
 “Sf. Parascheva” Infectious Diseases Clinical Hospital
 Dar Al Amal University Hospital
 ID-IRI Lead Coordinator
 Arnavutkoy State Hospital
 Kanuni Training and Research Hospital
 University Clinical Hospital Mostar
 University Clinic for Infectious Diseases
 Sisli Hamidiye Etfal Education and Research Hospital
 Centro Hospitalar Universitário de São João
 KCU Sarajevo.
 Kartal Koşuyolu High Speciality Training and Research Hospital
 European Gaza Hospital
 RMCH
 Hospital Municipal de San Juan
 Pendik State Hospital
 Umberto I Hospital
 S.L. Raheja Hospital

Abstract

Evaluating trends in antibiotic resistance is a requisite. The study aimed to analyze the profile of multidrug-resistant organisms (MDROs) among hospitalized patients with bacteremia in intensive care units (ICUs) in a large geographical area. This is a 1-month cross-sectional survey for blood-borne pathogens in 57 ICUs from 24 countries with different income levels: lower-middle-income (LMI), upper-middle-income (UMI), and high-income (HI) countries. Multidrug-resistant (MDR), extensively drug-resistant (XDR), or pan-drug-resistant isolates were searched. Logistic regression analysis determined resistance predictors among MDROs. Community-acquired infections were comparable to hospital-acquired infections particularly in LMI (94/202; 46.5% vs 108/202; 53.5%). Although MDR (65.1%; 502/771) and XDR (4.9%; 38/771) were common, no pan-drug-resistant isolate was recovered. In total, 32.1% of MDR were Klebsiella pneumoniae, and 55.3% of XDR were Acinetobacter baumannii. The highest MDR and XDR rates were in UMI and LMI, respectively, with no XDR revealed from HI. Predictors of MDR acquisition were male gender (OR, 12.11; 95% CI, 3.025–15.585) and the hospital-acquired origin of bacteremia (OR, 2.643; 95%CI, 1.462–3.894), and XDR acquisition was due to bacteremia in UMI (OR, 3.344; 95%CI, 1.189–5.626) and admission to medical-surgical ICUs (OR, 1.481; 95% CI, 1.076–2.037). We confirm the urgent need to expand stewardship activities to community settings especially in LMI, with more paid attention to the drugs with a higher potential for resistance. Empowering microbiology laboratories and reports to direct prescribing decisions should be prioritized. Supporting stewardship in ICUs, the mixed medical-surgical ones in particular, is warranted.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/77718

Collections

Scopus 2021