Publication:
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Issued Date

2021-04-29

Resource Type

Article

ISSN

10974172
00928674

DOI

10.1016/j.cell.2021.02.037

Other identifier(s)

2-s2.0-85102634643

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cell. Vol.184, No.9 (2021), 2348-2361.e6

Suggested Citation

Daming Zhou, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M.E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Guido C. Paesen, Cesar Lopez-Camacho, Jose Slon-Campos, Bassam Hallis, Naomi Coombes, Kevin Bewley, Sue Charlton, Thomas S. Walter, Donal Skelly, Sheila F. Lumley, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, William James, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera. Cell. Vol.184, No.9 (2021), 2348-2361.e6. doi:10.1016/j.cell.2021.02.037 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76204

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Title

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Author(s)

Daming Zhou
 Wanwisa Dejnirattisai
 Piyada Supasa
 Chang Liu
 Alexander J. Mentzer
 Helen M. Ginn
 Yuguang Zhao
 Helen M.E. Duyvesteyn
 Aekkachai Tuekprakhon
 Rungtiwa Nutalai
 Beibei Wang
 Guido C. Paesen
 Cesar Lopez-Camacho
 Jose Slon-Campos
 Bassam Hallis
 Naomi Coombes
 Kevin Bewley
 Sue Charlton
 Thomas S. Walter
 Donal Skelly
 Sheila F. Lumley
 Christina Dold
 Robert Levin
 Tao Dong
 Andrew J. Pollard
 Julian C. Knight
 Derrick Crook
 Teresa Lambe
 Elizabeth Clutterbuck
 Sagida Bibi
 Amy Flaxman
 Mustapha Bittaye
 Sandra Belij-Rammerstorfer
 Sarah Gilbert
 William James
 Miles W. Carroll
 Paul Klenerman
 Eleanor Barnes
 Susanna J. Dunachie
 Elizabeth E. Fry
 Juthathip Mongkolsapaya
 Jingshan Ren
 David I. Stuart
 Gavin R. Screaton

Other Contributor(s)

Siriraj Hospital
 Mahidol Oxford Tropical Medicine Research Unit
 NIHR Oxford Biomedical Research Centre
 Oxford University Hospitals NHS Foundation Trust
 Public Health England
 Diamond Light Source
 Worthing Hospital
 University of Oxford
 Sir William Dunn School of Pathology
 Nuffield Department of Medicine
 University of Oxford Medical Sciences Division
 Instruct-ERIC

Abstract

The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7; South Africa, B.1.351; and Brazil, P.1. These variants have multiple changes in the immunodominant spike protein that facilitates viral cell entry via the angiotensin-converting enzyme-2 (ACE2) receptor. Mutations in the receptor recognition site on the spike are of great concern for their potential for immune escape. Here, we describe a structure-function analysis of B.1.351 using a large cohort of convalescent and vaccinee serum samples. The receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes. In a number of cases, it would appear that convalescent and some vaccine serum offers limited protection against this variant.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/76204

Collections

Scopus 2021