Publication: Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar, in Rats
Issued Date
2016-08-01
Resource Type
ISSN
14390221
00320943
00320943
Other identifier(s)
2-s2.0-84992303032
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.82, No.13 (2016), 1186-1191
Suggested Citation
Phisit Khemawoot, Natthaphon Hunsakunachai, Tosapol Anukunwithaya, Kunan Bangphumi, Boonsri Ongpipattanakul, Weena Jiratchariyakul, Ruedee Soawakontha, Thanakorn Inthachart, Thaweephol Dechatiwongse Na Ayudhya, Sittichai Koontongkaew, Orapan Poachanukoon Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar, in Rats. Planta Medica. Vol.82, No.13 (2016), 1186-1191. doi:10.1055/s-0042-104658 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42939
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Title
Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar, in Rats
Abstract
© Georg Thieme Verlag KG Stuttgart New York. Rhizomes of Zingiber cassumunar have been used for many years in traditional Thai medicine as an anti-inflammatory agent. The major bioactive component of this plant is Compound D [E-4-(3′, 4′-dimethoxyphenyl)but-3-en-1-ol], which is a strong smooth muscle relaxant, and has antihistamine and anti-inflammatory actions. There is, however, incomplete information available for the pharmacokinetics of Compound D in mammals. In this study, we examined the pharmacokinetic profiles of Compound D in male Wistar rats. A standardized extract of Z. cassumunar containing 4% w/w Compound D was administered intravenously at 25 mg/kg or by oral gavage at 25, 75, or 250 mg/kg to Wistar rats. Blood, tissues, urine, and feces were collected from 0 to 48 h after dosing and the level of Compound D was determined by liquid chromatography-tandem mass spectrometry. The concentration of Compound D ranged from 10-100 μg/L, reached a maximum approximately 0.15 h after oral dosing. Compound D exhibited an excellent tissue to plasma ratio, ranging from 1- to 1000 in several organs at 1-4 h after oral dosing. Less than 1% of unchanged Compound D was excreted in the urine and feces. Further studies on tissue uptake and metabolite identification are required to obtain complete pharmacokinetic information and to develop appropriate dosing strategies of Compound D and the standardized extract of Z. cassumunar.