Publication:
The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Issued Date

2021-12-01

Resource Type

Article

ISSN

14712253

DOI

10.1186/s12871-021-01268-y

Other identifier(s)

2-s2.0-85102932125

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

BMC Anesthesiology. Vol.21, No.1 (2021)

Suggested Citation

Guido Mazzinari, Ary Serpa Neto, Sabrine N.T. Hemmes, Goran Hedenstierna, Samir Jaber, Michael Hiesmayr, Markus W. Hollmann, Gary H. Mills, Marcos F. Vidal Melo, Rupert M. Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Oscar Diaz Cambronero, Lorenzo Ball, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J. Schultz, Wolfgang Kroell, Helfried Metzler, Gerd Struber, Thomas Wegscheider, Hans Gombotz, Bernhard Urbanek, David Kahn, Mona Momeni, Audrey Pospiech, Fernande Lois, Patrice Forget, Irina Grosu, Jan Poelaert, Veerle van Mossevelde, Marie Claire van Malderen, Dimitri Dylst, Jeroen van Melkebeek, Maud Beran, Stefan de Hert, Luc De Baerdemaeker, Bjorn Heyse, Jurgen Van Limmen, Piet Wyffels, Tom Jacobs, Nathalie Roels, Ann De Bruyne, Stijn van de Velde, Brigitte Leva, Sandrine Damster, Benoit Plichon, Marina Juros-Zovko, Dejana Djonovic-Omanovic, Selma Pernar, Josip Zunic, Petar Miskovic, Antonio Zilic, Slavica Kvolik, Dubravka Ivic, Darija Azenic-Venzera, Sonja Skiljic, Hrvoje Vinkovic, Ivana Oputric, Kazimir Juricic, Vedran Frkovic, Jasminka Kopic, Ivan Mirkovic, Nenad Karanovic, Mladen Carev, Natasa Dropulic, Jadranka Pavicic Saric, Gorjana Erceg, Matea Bogdanovic Dvorscak, Branka Mazul-Sunko, Anna Marija Pavicic, Tanja Goranovic, Branka Maldini, Tomislav Radocaj, Zeljka Gavranovic, Inga Mladic-Batinica, Mirna Sehovic, Petr Stourac, Hana Harazim, Olga Smekalova, Martina Kosinova, Tomas Kolacek, Kamil Hudacek, Michal Drab, Jan Brujevic, Katerina Vitkova, Katerina Jirmanova, Ivana Volfova, Paula Dzurnakova, Katarina Liskova, Radovan Dudas, Radek Filipsky, Samir el Kafrawy, Hisham Hosny Abdelwahab, Tarek Metwally, Ahmed Abdel-Razek, Ahmed Mostafa El-Shaarawy, Wael Fathy Hasan The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study. BMC Anesthesiology. Vol.21, No.1 (2021). doi:10.1186/s12871-021-01268-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77618

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Title

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Author(s)

Guido Mazzinari
 Ary Serpa Neto
 Sabrine N.T. Hemmes
 Goran Hedenstierna
 Samir Jaber
 Michael Hiesmayr
 Markus W. Hollmann
 Gary H. Mills
 Marcos F. Vidal Melo
 Rupert M. Pearse
 Christian Putensen
 Werner Schmid
 Paolo Severgnini
 Hermann Wrigge
 Oscar Diaz Cambronero
 Lorenzo Ball
 Marcelo Gama de Abreu
 Paolo Pelosi
 Marcus J. Schultz
 Wolfgang Kroell
 Helfried Metzler
 Gerd Struber
 Thomas Wegscheider
 Hans Gombotz
 Bernhard Urbanek
 David Kahn
 Mona Momeni
 Audrey Pospiech
 Fernande Lois
 Patrice Forget
 Irina Grosu
 Jan Poelaert
 Veerle van Mossevelde
 Marie Claire van Malderen
 Dimitri Dylst
 Jeroen van Melkebeek
 Maud Beran
 Stefan de Hert
 Luc De Baerdemaeker
 Bjorn Heyse
 Jurgen Van Limmen
 Piet Wyffels
 Tom Jacobs
 Nathalie Roels
 Ann De Bruyne
 Stijn van de Velde
 Brigitte Leva
 Sandrine Damster
 Benoit Plichon
 Marina Juros-Zovko
 Dejana Djonovic-Omanovic
 Selma Pernar
 Josip Zunic
 Petar Miskovic
 Antonio Zilic
 Slavica Kvolik
 Dubravka Ivic
 Darija Azenic-Venzera
 Sonja Skiljic
 Hrvoje Vinkovic
 Ivana Oputric
 Kazimir Juricic
 Vedran Frkovic
 Jasminka Kopic
 Ivan Mirkovic
 Nenad Karanovic
 Mladen Carev
 Natasa Dropulic
 Jadranka Pavicic Saric
 Gorjana Erceg
 Matea Bogdanovic Dvorscak
 Branka Mazul-Sunko
 Anna Marija Pavicic
 Tanja Goranovic
 Branka Maldini
 Tomislav Radocaj
 Zeljka Gavranovic
 Inga Mladic-Batinica
 Mirna Sehovic
 Petr Stourac
 Hana Harazim
 Olga Smekalova
 Martina Kosinova
 Tomas Kolacek
 Kamil Hudacek
 Michal Drab
 Jan Brujevic
 Katerina Vitkova
 Katerina Jirmanova
 Ivana Volfova
 Paula Dzurnakova
 Katarina Liskova
 Radovan Dudas
 Radek Filipsky
 Samir el Kafrawy
 Hisham Hosny Abdelwahab
 Tarek Metwally
 Ahmed Abdel-Razek
 Ahmed Mostafa El-Shaarawy
 Wael Fathy Hasan

Other Contributor(s)

Université de Montpellier
 IRCCS San Martino Polyclinic Hospital
 Hospital Universitari i Politècnic La Fe
 Universitätsklinikum Bonn
 Massachusetts General Hospital
 Università degli Studi di Genova
 Queen Mary University of London
 Technische Universität Dresden
 Hospital Israelita Albert Einstein
 Mahidol University
 Medizinische Universität Wien
 Nuffield Department of Medicine
 Universidade de São Paulo
 BG-Kliniken Bergmannstrost Halle
 Università degli Studi dell'Insubria
 Uppsala Universitet
 The University of Sheffield
 Amsterdam UMC - University of Amsterdam

Abstract

Background: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods: Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. Results: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12– to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001). Conclusions: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. Trial registration: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223).

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/77618

Collections

Scopus 2021