Publication: Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity
Issued Date
2013-08-01
Resource Type
ISSN
1618131X
14384639
14384639
Other identifier(s)
2-s2.0-84880047017
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Hygiene and Environmental Health. Vol.216, No.5 (2013), 587-598
Suggested Citation
Preeyaporn Koedrith, Hye Lim Kim, Jong Il Weon, Young Rok Seo Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity. International Journal of Hygiene and Environmental Health. Vol.216, No.5 (2013), 587-598. doi:10.1016/j.ijheh.2013.02.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32233
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Title
Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity
Abstract
Heavy metals that are harmful to humans include arsenic, cadmium, chromium, lead, mercury, and nickel. Some metals or their related compounds may even cause cancer. However, the mechanism underlying heavy metal-induced cancer remains unclear. Increasing data show a link between heavy metal exposure and aberrant changes in both genetic and epigenetic factors via non-targeted multiple toxicogenomic technologies of the transcriptome, proteome, metabolome, and epigenome. These modifications due to heavy metal exposure might provide a better understanding of environmental disorders. Such informative changes following heavy metal exposure might also be useful for screening of biomarker-monitored exposure to environmental pollutants and/or predicting the risk of disease. We summarize advances in high-throughput toxicogenomic-based technologies and studies related to exposure to individual heavy metal and/or mixtures and propose the underlying mechanism of action and toxicant signatures. Integrative multi-level expression analysis of the toxicity of heavy metals via system toxicology-based methodologies combined with statistical and computational tools might clarify the biological pathways involved in carcinogenic processes. Although standard in vitro and in vivo endpoint testing of mutagenicity and carcinogenicity are considered a complementary approach linked to disease, we also suggest that further evaluation of prominent biomarkers reflecting effects, responses, and disease susceptibility might be diagnostic. Furthermore, we discuss challenges in toxicogenomic applications for toxicological studies of metal mixtures and epidemiological research. Taken together, this review presents toxicogenomic data that will be useful for improvement of the knowledge of carcinogenesis and the development of better strategies for health risk assessment. © 2013 Elsevier GmbH.