Publication: Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete Favolaschia Species
Issued Date
2020-01-01
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-85082183001
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products. (2020)
Suggested Citation
Jittra Kornsakulkarn, Somporn Palasarn, Wilunda Choowong, Tienthong Thongpanchang, Nattawut Boonyuen, Rattaket Choeyklin, Thitiya Boonpratuang, Masahiko Isaka, Chawanee Thongpanchang Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete Favolaschia Species. Journal of Natural Products. (2020). doi:10.1021/acs.jnatprod.9b00647 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54489
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete Favolaschia Species
Abstract
© 2020 American Chemical Society and American Society of Pharmacognosy. Fourteen new compounds, oudemansins 1-4, oudemansinols 5-7, favolasins 8-10, favolasinin (12), polyketides 13-15, and (R,E)-2,4-dimethyl-5-phenyl-4-pentene-2,3-diol (16), together with nine known compounds were isolated from the basidiomycete fungus Favolaschia sp. BCC 18686. Two new compounds, favolasin E (11) and 9-oxostrobilurin E (17), were isolated from the closely related organism Favolaschia calocera BCC 36684 along with nine β-methoxyacrylate-type derivatives. Compounds in the class of oudemansins and strobilurins exhibited moderate to strong antimalarial activity with relatively low cytotoxicity against Vero cells (African green monkey kidney fibroblasts). Potent antimalarial activity was demonstrated for 9-methoxystrobilurins G, K, and E (IC50 values 0.061, 0.089, and 0.14 μM, respectively). The structure-activity relationships (SAR) for antimalarial activity is proposed on the basis of the activity of the new and several known β-methoxyacrylate derivatives in combination with the data from previously isolated compounds. Furthermore, several compounds showed specific cytotoxicity against NCI-187 cells (human small-cell lung cancer), although the SAR was different from that for antimalarial activity.