Publication: Detection of the impairment of CD80 expression on circulating monocytes in HIV-infected Thai children
Issued Date
2004-01-01
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ISSN
03855600
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2-s2.0-3242784990
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbiology and Immunology. Vol.48, No.7 (2004), 557-560
Suggested Citation
Sukathida Ubol, Benjamaz Aiamkitsumrit, Sorachai Nitayaphan, Sayomporn Sirinavin, Sangvorn Kitthawee Detection of the impairment of CD80 expression on circulating monocytes in HIV-infected Thai children. Microbiology and Immunology. Vol.48, No.7 (2004), 557-560. doi:10.1111/j.1348-0421.2004.tb03543.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21411
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Title
Detection of the impairment of CD80 expression on circulating monocytes in HIV-infected Thai children
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Abstract
The mechanism of progressive anergic response in HIV-infected children has yet to be adequately described. One possibility is inappropriate delivery of an essential second signal for T-cell activation due to the inappropriate presentation of co-stimulatory molecules. To determine whether the ligand for the secondary signal is impaired in pediatric AIDS, we compared the level of CD80 expression by circulating monocytes in HIV-infected and -noninfected children (15 mild/asymptomatic, 13 symptomatic and 12 HIV seronegative children). By two-color flow cytometry analysis, there was no statistically significant difference in the percentage of monocytes expressing CD80 among the groups (i.e., 63.2±15.8, 60.9±12.7, 61.04±10.9 for uninfected children, mild-asymptomatic children and symptomatic children, respectively). However, both infected groups showed statistically significant lower levels of CD80 expression, with mean fluorescent intensities of 40.9±15.9 and 38.8±10.7 compared to 57.05±16.3 for the uninfected control group. Our data demonstrated a correlation between HIV infection and impairment of CD80 by circulating monocytes. Whether the impairment on CD80 expression contributes to destruction of the immunological network in HIV-infected children requires further investigation.