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Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker

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dc.contributor.authorNeelima Mishraen_US
dc.contributor.authorSurendra Kumar Prajapatien_US
dc.contributor.authorKamlesh Kaitholiaen_US
dc.contributor.authorRam Suresh Bhartien_US
dc.contributor.authorBina Srivastavaen_US
dc.contributor.authorSobhan Phookanen_US
dc.contributor.authorAnupkumar R. Anvikaren_US
dc.contributor.authorVas Deven_US
dc.contributor.authorGagan Singh Sonalen_US
dc.contributor.authorAkshay Chandra Dhariwalen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorNeena Valechaen_US
dc.contributor.otherNational Institute of Malaria Research Indiaen_US
dc.contributor.otherMinistry of Health and Family Welfareen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.date.accessioned2018-11-23T10:45:59Z
dc.date.available2018-11-23T10:45:59Z
dc.date.issued2015-05-01en_US
dc.description.abstractCopyright © 2015, American Society for Microbiology. All Rights Reserved. Malaria treatment in Southeast Asia is threatened with the emergence of artemisinin-resistant Plasmodium falciparum. Genome association studies have strongly linked a locus on P. falciparum chromosome 13 to artemisinin resistance, and recently, mutations in the kelch13 propeller region (Pfk-13) were strongly linked to resistance. To date, this information has not been shown in Indian samples. Pfk-13 mutations were assessed in samples from efficacy studies of artemisinin combination treatments in India. Samples were PCR amplified and sequenced from codon 427 to 727. Out of 384 samples, nonsynonymous mutations in the propeller region were found in four patients from the northeastern states, but their presence did not correlate with ACT treatment failures. This is the first report of Pfk-13 point mutations from India. Further phenotyping and genotyping studies are required to assess the status of artemisinin resistance in this region.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.59, No.5 (2015), 2548-2553en_US
dc.identifier.doi10.1128/AAC.04632-14en_US
dc.identifier.issn10986596en_US
dc.identifier.issn00664804en_US
dc.identifier.other2-s2.0-84931292116en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/36455
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84931292116&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSurveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular markeren_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84931292116&origin=inwarden_US

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