Publication: Photodynamic therapy combined with ranibizumab for polypoidal choroidal vasculopathy: Results of a 1-year preliminary study
Issued Date
2010-08-01
Resource Type
ISSN
14682079
00071161
00071161
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2-s2.0-77955246773
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Mahidol University
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SCOPUS
Bibliographic Citation
British Journal of Ophthalmology. Vol.94, No.8 (2010), 1045-1051
Suggested Citation
Paisan Ruamviboonsuk, M. Tadarati, S. Vanichvaranont, P. Hanutsaha, N. Pokawattana Photodynamic therapy combined with ranibizumab for polypoidal choroidal vasculopathy: Results of a 1-year preliminary study. British Journal of Ophthalmology. Vol.94, No.8 (2010), 1045-1051. doi:10.1136/bjo.2009.173120 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29582
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Title
Photodynamic therapy combined with ranibizumab for polypoidal choroidal vasculopathy: Results of a 1-year preliminary study
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Abstract
Background/aims: To determine the potential efficacy and safety of combined verteporfin photodynamic therapy (PDT) with ranibizumab for the treatment of polypoidal choroidal vasculopathy (PCV). Methods: In this prospective, non-comparative, interventional study, 12 eyes from 12 patients that had active PCV were treated with PDT combined with three monthly intravitreal injections of ranibizumab. The patients were then monitored monthly with measurements of best-corrected visual acuity (BCVA) and central retinal thickness quantified by optical coherence tomography for 1 year. Indocyanine green angiography (ICGA) and fluorescein angiography were performed every 3 months. The eyes were re-treated with PDT and a ranibizumab injection, or with solely ranibizumab injection when indicated. Results: At month 12, the mean BCVA change from baseline was +12.3 letters (p=0.04). Eight patients (58.3%, p=0.02) had a BCVA gain of 15 letters or more. One patient (8.3%, p=1.0) had a BCVA loss of 15 letters or more. All patients underwent regression of polyps without recurrence. One patient experienced an insignificant subretinal haemorrhage. No other adverse event that could be attributed to the treatment was observed. Conclusions: This combination therapy showed encouraging results concerning improving vision, reducing the incidence of subretinal haemorrhage and reducing the recurrence of polyps when compared to previously published data that reported PDT monotherapy for PCV.