Publication: Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats
Issued Date
2021-09-01
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ISSN
18729754
01970186
01970186
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2-s2.0-85107303542
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Mahidol University
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SCOPUS
Bibliographic Citation
Neurochemistry International. Vol.148, (2021)
Suggested Citation
Wilasinee Suwanjang, Waralee Ruankham, Banthit Chetsawang, Sujira Mukda, Sukhonthar Ngampramuan, Sujitra Srisung, Virapong Prachayasittikul, Supaluk Prachayasittikul Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats. Neurochemistry International. Vol.148, (2021). doi:10.1016/j.neuint.2021.105083 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76065
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Title
Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats
Abstract
Chronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function.